Evidence map›Paper›PMID 38257802›Full record

ArticleViruses2024

Timely Monitoring of SARS-CoV-2 RNA Fragments in Wastewater Shows the Emergence of JN.1 (BA.2.86.1.1, Clade 23I) in Berlin, Germany.

Alexander Bartel, José Horacio Grau, Julia Bitzegeio, Dirk Werber, Nico Linzner, Vera Schumacher, Sonja Garske, Karsten Liere, Thomas Hackenbeck, Sofia Isabell Rupp and 3 more

Abstract read
In one paragraph

Article in Viruses, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  7. Article
  8. Monitoring SARS-CoV-2 variants with complementary surveillance systems: risk evaluation of the Omicron JN.1 variant in France, August 2023 to January 2024.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2025
    Article
  9. Article
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  12. Wastewater Surveillance of SARS-CoV-2 in Zambia: An Early Warning Tool.International journal of molecular sciences · 2024
    Article
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  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Alexander BartelUnit for Surveillance and Epidemiology of Infectious Diseases, State Office for Health and Social Affairs (SOHSA), 10559 Berlin, Germany.ORCID 0000-0002-1280-6138
José Horacio Grauamedes Medizinische Dienstleistungen GmbH, 37077 Göttingen, Germany.
Julia BitzegeioUnit for Surveillance and Epidemiology of Infectious Diseases, State Office for Health and Social Affairs (SOHSA), 10559 Berlin, Germany.ORCID 0000-0003-4481-7170
Dirk WerberUnit for Surveillance and Epidemiology of Infectious Diseases, State Office for Health and Social Affairs (SOHSA), 10559 Berlin, Germany.
Nico LinznerLaboratory of Berliner Wasserbetriebe, Berliner Wasserbetriebe, 13629 Berlin, Germany.
Vera SchumacherLaboratory of Berliner Wasserbetriebe, Berliner Wasserbetriebe, 13629 Berlin, Germany.
Sonja GarskeUnit for Surveillance and Epidemiology of Infectious Diseases, State Office for Health and Social Affairs (SOHSA), 10559 Berlin, Germany.
Karsten Liereamedes Medizinische Dienstleistungen GmbH, 37077 Göttingen, Germany.ORCID 0000-0003-1504-1449
Thomas Hackenbeckamedes Medizinische Dienstleistungen GmbH, 37077 Göttingen, Germany.
Sofia Isabell Ruppamedes Medizinische Dienstleistungen GmbH, 37077 Göttingen, Germany.
Daniel SagebielUnit for Surveillance and Epidemiology of Infectious Diseases, State Office for Health and Social Affairs (SOHSA), 10559 Berlin, Germany.
Uta BöckelmannLaboratory of Berliner Wasserbetriebe, Berliner Wasserbetriebe, 13629 Berlin, Germany.
Martin Meixneramedes Medizinische Dienstleistungen GmbH, 37077 Göttingen, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The importance of COVID-19 surveillance from wastewater continues to grow since case-based surveillance in the general population has been scaled back world-wide. In Berlin, Germany, quantitative and genomic wastewater monitoring for SARS-CoV-2 is performed in three wastewater treatment plants (WWTP) covering 84% of the population since December 2021. The SARS-CoV-2 Omicron sublineage JN.1 (B.2.86.1.1), was first identified from wastewater on 22 October 2023 and rapidly became the dominant sublineage. This change was accompanied by a parallel and still ongoing increase in the notification-based 7-day-hospitalization incidence of COVID-19 and COVID-19 ICU utilization, indicating increasing COVID-19 activity in the (hospital-prone) population and a higher strain on the healthcare system. In retrospect, unique mutations of JN.1 could be identified in wastewater as early as September 2023 but were of unknown relevance at the time. The timely detection of new sublineages in wastewater therefore depends on the availability of new sequences from GISAID and updates to Pango lineage definitions and Nextclade. We show that genomic wastewater surveillance provides timely public health evidence on a regional level, complementing the existing indicators.

Indexed as

COVID-19WastewaterBerlinGermanyHumansRNA, ViralSARS-CoV-2Wastewater-Based Epidemiological MonitoringRNA, ViralWastewatergenomic surveillanceGermanyOmicronSARS-CoV-2wastewater sequencing

Identifiers

PMID38257802
PMCPMC10818819

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.