Evidence map›Paper›PMID 38257342›Full record

ArticleMolecules (Basel, Switzerland)2024

Evaluation of the Feasibility of In Vitro Metabolic Interruption of Trimethylamine with Resveratrol Butyrate Esters and Its Purified Monomers.

Ping-Hsiu Huang, De-Quan Chen, Yu-Wei Chen, Ming-Kuei Shih, Bao-Hong Lee, You-Lin Tain, Chang-Wei Hsieh, Chih-Yao Hou

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 2 countries.

Ping-Hsiu HuangSchool of Food, Jiangsu Food and Pharmaceutical Science College, No. 4, Meicheng Road, Higher Education Park, Huai'an 223003, China.ORCID 0000-0001-5454-6058
De-Quan ChenDepartment of Seafood Science, College of Hydrosphere, National Kaohsiung, University of Science and Technology, Kaohsiung 81157, Taiwan.
Yu-Wei ChenDepartment of Food Science and Biotechnology, National Chung Hsing University, Taichung 40227, Taiwan.
Ming-Kuei ShihGraduate Institute of Food Culture and Innovation, National Kaohsiung University of Hospitality and Tourism, Kaohsiung 812301, Taiwan.ORCID 0000-0001-5830-8591
Bao-Hong LeeDepartment of Horticulture, National Chiayi University, Chiayi 60004, Taiwan.
You-Lin TainDepartment of Pediatrics, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 83301, Taiwan.ORCID 0000-0002-7059-6407
Chang-Wei HsiehDepartment of Food Science and Biotechnology, National Chung Hsing University, Taichung 40227, Taiwan.ORCID 0000-0002-0533-9762
Chih-Yao HouDepartment of Seafood Science, College of Hydrosphere, National Kaohsiung, University of Science and Technology, Kaohsiung 81157, Taiwan.ORCID 0000-0002-8007-6077
National Chung Hsing University · TWNational Kaohsiung Marine University · TWChang Gung University · TWJiangsu Food and Pharmaceutical Science College · CNNational Chiayi University · TWNational Kaohsiung University of Hospitality and Tourism · TW

Funding

National Science and Technology Council funded this research, the Republic of China 110-2320-B-992-001-MY3National Science and Technology Council funded this research, the Republic of China 111-2221-E-328-001-MY3National Science and Technology Council funded this research, the Republic of China 111-2622-E-992-007-National Science and Technology Council funded this research, the Republic of China 112-2221-E-992 -002 -MY3
6 · The paper itself

Abstract

Resveratrol (RSV), obtained from dietary sources, has been shown to reduce trimethylamine oxide (TMAO) levels in humans, and much research indicates that TMAO is recognized as a risk factor for cardiovascular disease. Therefore, this study investigated the effects of RSV and RSV-butyrate esters (RBE) on the proliferation of co-cultured bacteria and HepG2 cell lines, respectively, and also investigated the changes in trimethylamine (TMA) and TMOA content in the medium and flavin-containing monooxygenase-3 (FMO3) gene expression. This study revealed that 50 µg/mL of RBE could increase the population percentage of

Indexed as

ButyratesEstersMethylaminesFeasibility StudiesHumansResveratrolButyratesEstersMethylaminesResveratroltrimethylaminetrimethyloxamineco-culturedmetabolismprobioticshort-chain fatty acid (SCFA)trimethylamine-N-oxide (TMAO)

Identifiers

PMID38257342
PMCPMC10820948
OpenAlexW4390914137

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.