Evidence map›Paper›PMID 38257341›Full record

ArticleMolecules (Basel, Switzerland)2024

Screening of Multitarget Compounds against Acetaminophen Hepatic Toxicity Using In Silico, In Vitro, and In Vivo Approaches.

Muhammad Ali, Esha Asghar, Waqas Ali, Ghulam Mustafa, Irfan Aamer Ansari, Saadiya Zia, Siddique Akber Ansari, Sumaiya Khan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
2.3field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 3 countries.

Muhammad AliDepartment of Biochemistry, Faculty of Sciences, University of Agriculture Faisalabad (UAF), Faisalabad 38040, Pakistan.ORCID 0000-0003-4742-425X
Esha AsgharDepartment of Biotechnology, Akhuwat Faisalabad Institute of Research Science and Technology (A-FIRST), Faisalabad 38000, Pakistan.
Waqas AliDepartment of Biochemistry, Faculty of Sciences, University of Agriculture Faisalabad (UAF), Faisalabad 38040, Pakistan.ORCID 0000-0002-5589-6129
Ghulam MustafaDepartment of Biochemistry, Government College University Faisalabad (GCUF), Faisalabad 38000, Pakistan.ORCID 0000-0001-6510-6496
Irfan Aamer AnsariDepartment of Drug Science and Technology, University of Turin, 10124 Turin, Italy.ORCID 0000-0001-5375-0006
Saadiya ZiaDepartment of Biochemistry, Faculty of Sciences, University of Agriculture Faisalabad (UAF), Faisalabad 38040, Pakistan.
Siddique Akber AnsariDepartment of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.ORCID 0000-0003-3966-2282
Sumaiya KhanDepartment of Drug Chemistry and Technologies, University "La Sapienza", 00185 Rome, Italy.
University of Faisalabad · PKGovernment College University, Faisalabad · PKKing Saud University · SASapienza University of Rome · ITUniversity of Turin · IT

Funding

King Saud University RSPD2024R744
6 · The paper itself

Abstract

Combination therapy and multitarget drugs have recently attracted much attention as promising tools to fight against many challenging diseases and, thus, represent a new research focus area. The aim of the current project was to screen multitarget compounds and to study their individual and combined effects on acetaminophen-induced liver injury. In this study, 2 of the best hepatoprotective multitargeting compounds were selected from a pool of 40 major compounds present in

Indexed as

CurcuminHepatitisAcetaminophenHumansMolecular Docking SimulationQuercetinAcetaminophenCurcuminQuercetinacetaminophenantioxidant activityCinnamon zeylanicumCurcuma longacurcuminmolecular dockingmultitargetquercetin

Identifiers

PMID38257341
PMCPMC10821416
OpenAlexW4390914106

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.