Evidence map›Paper›PMID 38257294›Full record

ArticleMolecules (Basel, Switzerland)2024

F16 Hybrids Derived from Steviol or Isosteviol Are Accumulated in the Mitochondria of Tumor Cells and Overcome Drug Resistance.

Niels V Heise, Julia Heisig, Kristof Meier, René Csuk, Thomas Mueller

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Heterocycles in Medicinal Chemistry II.Molecules (Basel, Switzerland) · 2024
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Niels V HeiseOrganic Chemistry, Martin-Luther University Halle-Wittenberg, Kurt-Mothes, Str. 2, D-06120 Halle (Saale), Germany.ORCID 0000-0002-6540-6357
Julia HeisigOrganic Chemistry, Martin-Luther University Halle-Wittenberg, Kurt-Mothes, Str. 2, D-06120 Halle (Saale), Germany.
Kristof MeierHematology/Oncology, Medical Faculty, University Clinic for Internal Medicine IV, Martin-Luther University Halle-Wittenberg, Ernst-Grube Str. 40, D-06120 Halle (Saale), Germany.
René CsukOrganic Chemistry, Martin-Luther University Halle-Wittenberg, Kurt-Mothes, Str. 2, D-06120 Halle (Saale), Germany.ORCID 0000-0001-7911-290X
Thomas MuellerHematology/Oncology, Medical Faculty, University Clinic for Internal Medicine IV, Martin-Luther University Halle-Wittenberg, Ernst-Grube Str. 40, D-06120 Halle (Saale), Germany.ORCID 0000-0003-4637-0157

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Steviol and isosteviol were prepared from the commercially available sweetener stevioside and converted into lipophilic F16 hybrids. Their cytotoxicity was determined in SRB assays and showed to depend on both the substitution pattern of the aromatic substituent as well as on the spacer length. Therefore, compound

Indexed as

Diterpenes, KauraneOvarian NeoplasmsCell Line, TumorFemaleHumansMitochondriaDiterpenes, KauraneisosteviolsteviolcytotoxicityF16 hybridsisosteviolmitochondrial accumulationsteviol

Identifiers

PMID38257294
PMCPMC10821019

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.