Evidence map›Paper›PMID 38257229›Full record

ArticleMolecules (Basel, Switzerland)2024

Moderate Signal Enhancement in Electrospray Ionization Mass Spectrometry by Focusing Electrospray Plume with a Dielectric Layer around the Mass Spectrometer's Orifice.

Zi Qing Chua, Gurpur Rakesh D Prabhu, Yi-Wun Wang, Chamarthi Maheswar Raju, Krzysztof Buchowiecki, Ochir Ochirov, Decibel P Elpa, Pawel L Urban

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zi Qing ChuaDepartment of Chemistry, National Tsing Hua University, 101, Section 2, Kuang-Fu Rd., Hsinchu 300044, Taiwan.
Gurpur Rakesh D PrabhuDepartment of Chemistry, National Tsing Hua University, 101, Section 2, Kuang-Fu Rd., Hsinchu 300044, Taiwan.ORCID 0000-0002-3237-212X
Yi-Wun WangDepartment of Chemistry, National Tsing Hua University, 101, Section 2, Kuang-Fu Rd., Hsinchu 300044, Taiwan.
Chamarthi Maheswar RajuDepartment of Chemistry, National Tsing Hua University, 101, Section 2, Kuang-Fu Rd., Hsinchu 300044, Taiwan.
Krzysztof BuchowieckiDepartment of Chemistry, National Tsing Hua University, 101, Section 2, Kuang-Fu Rd., Hsinchu 300044, Taiwan.
Ochir OchirovDepartment of Chemistry, National Tsing Hua University, 101, Section 2, Kuang-Fu Rd., Hsinchu 300044, Taiwan.ORCID 0009-0009-0042-6232
Decibel P ElpaDepartment of Chemistry, National Tsing Hua University, 101, Section 2, Kuang-Fu Rd., Hsinchu 300044, Taiwan.
Pawel L UrbanDepartment of Chemistry, National Tsing Hua University, 101, Section 2, Kuang-Fu Rd., Hsinchu 300044, Taiwan.ORCID 0000-0003-3471-045X

Funding

Ministry of Education, Taiwan 111QR001I5National Science and Technology Council, Taiwan 109-2113-M-007-013-MY3National Science and Technology Council, Taiwan 110-2628-M-007-004-MY4National Science and Technology Council, Taiwan 111-2634-F-007-007National Science and Technology Council, Taiwan 112-2113-M-007-025-MY2National Tsing Hua University, Taiwan 111QI009E1
6 · The paper itself

Abstract

Electrospray ionization (ESI) is among the commonly used atmospheric pressure ionization techniques in mass spectrometry (MS). One of the drawbacks of ESI is the formation of divergent plumes composed of polydisperse microdroplets, which lead to low transmission efficiency. Here, we propose a new method to potentially improve the transmission efficiency of ESI, which does not require additional electrical components and complex interface modification. A dielectric plate-made of ceramic-was used in place of a regular metallic sampling cone. Due to the charge accumulation on the dielectric surface, the dielectric layer around the MS orifice distorts the electric field, focusing the charged electrospray cloud towards the MS inlet. The concept was first verified using charge measurement on the dielectric material surface and computational simulation; then, online experiments were carried out to demonstrate the potential of this method in MS applications. In the online experiment, signal enhancements were observed for dielectric plates with different geometries, distances of the electrospray needle axis from the MS inlet, and various compounds. For example, in the case of acetaminophen (15 μM), the signal enhancement was up to 1.82 times (plate B) using the default distance of the electrospray needle axis from the MS inlet (

Indexed as

electrospray ionizationion sourcemass spectrometrymicrodropletssensitivity

Identifiers

PMID38257229
PMCPMC10821223

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.