Evidence map›Paper›PMID 38257210›Full record

ArticleMolecules (Basel, Switzerland)2024

Pharmacokinetic, Tissue Distribution, Metabolite, and Toxicity Evaluation of the Matrine Derivative, (6aS, 10S, 11aR, 11bR, 11cS)-10-Methylaminododecahydro-3a, 7a-Diaza-benzo (de) Anthracene-8-thione.

Liuyan Li, Fangfang Lu, Shuqin Ding, Xiaoying Wang, Weibiao Wang, Wannian Zhang, Weiheng Xu, Chunlin Zhuang, Zhenyuan Miao, Xueqin Ma

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Liuyan LiDepartment of Pharmaceutical Analysis, School of Pharmacy, Key Laboratory of Protection, Development, and Utilization of Medicinal Resources in Liupanshan Area, Ministry of Education, Ningxia Medical University, 1160 Shenli Street, Yinchuan 750004, China.ORCID 0000-0003-4170-7080
Fangfang LuDepartment of Pharmaceutical Analysis, School of Pharmacy, Key Laboratory of Protection, Development, and Utilization of Medicinal Resources in Liupanshan Area, Ministry of Education, Ningxia Medical University, 1160 Shenli Street, Yinchuan 750004, China.ORCID 0000-0002-2002-7898
Shuqin DingDepartment of Pharmaceutical Analysis, School of Pharmacy, Key Laboratory of Protection, Development, and Utilization of Medicinal Resources in Liupanshan Area, Ministry of Education, Ningxia Medical University, 1160 Shenli Street, Yinchuan 750004, China.ORCID 0000-0002-5105-1030
Xiaoying WangDepartment of Pharmaceutical Analysis, School of Pharmacy, Key Laboratory of Protection, Development, and Utilization of Medicinal Resources in Liupanshan Area, Ministry of Education, Ningxia Medical University, 1160 Shenli Street, Yinchuan 750004, China.ORCID 0000-0002-6622-5275
Weibiao WangDepartment of Pharmaceutical Analysis, School of Pharmacy, Key Laboratory of Protection, Development, and Utilization of Medicinal Resources in Liupanshan Area, Ministry of Education, Ningxia Medical University, 1160 Shenli Street, Yinchuan 750004, China.ORCID 0000-0003-0049-0604
Wannian ZhangDepartment of Pharmaceutical Analysis, School of Pharmacy, Key Laboratory of Protection, Development, and Utilization of Medicinal Resources in Liupanshan Area, Ministry of Education, Ningxia Medical University, 1160 Shenli Street, Yinchuan 750004, China.
Weiheng XuSchool of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, China.
Chunlin ZhuangDepartment of Pharmaceutical Analysis, School of Pharmacy, Key Laboratory of Protection, Development, and Utilization of Medicinal Resources in Liupanshan Area, Ministry of Education, Ningxia Medical University, 1160 Shenli Street, Yinchuan 750004, China.ORCID 0000-0002-0569-5708
Zhenyuan MiaoSchool of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, China.ORCID 0000-0001-7839-4183
Xueqin MaDepartment of Pharmaceutical Analysis, School of Pharmacy, Key Laboratory of Protection, Development, and Utilization of Medicinal Resources in Liupanshan Area, Ministry of Education, Ningxia Medical University, 1160 Shenli Street, Yinchuan 750004, China.
Ningxia Medical University · CNSecond Military Medical University · CN

Funding

National Natural Science Foundation of China U20A20136, 82360684Natural Science Foundation of Ningxia Province 2023AAC03179Ningxia key research and invention program of science and technology 2023BEG02014
6 · The paper itself

Abstract

MASM, a structurally modified derivative of matrine, exhibits superior efficacy in reducing inflammation and liver injury in rats when compared to matrine. This study aims to investigate the pharmacokinetic profile and acute toxicity of MASM. Pharmacokinetic results revealed that MASM exhibited rapid absorption, with a

Indexed as

AnthracenesMatrinesThionesAnimalsCarbon RadioisotopesMiceRatsTissue DistributionanthraceneAnthracenesCarbon-11Carbon Radioisotopesmatrine derivate masmMatrinesThionesMASMmetabolitespharmacokineticstissue distributiontoxicity evaluation

Identifiers

PMID38257210
PMCPMC10820135
OpenAlexW4390669087

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.