Evidence map›Paper›PMID 38257167›Full record

ArticleNutrients2024

Umbilical Cord Plasma Lysophospholipids and Triacylglycerols Associated with Birthweight Percentiles.

Gerard Wong, Kothandaraman Narasimhan, Wei Fun Cheong, Sharon Ng, Izzuddin M Aris, See Ling Loy, Anne K Bendt, Kok Hian Tan, Fabian K P Yap, Lynette P Shek and 7 more

Open access · goldAbstract read
In one paragraph

Article in Nutrients, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 5 institutions in 3 countries.

Gerard WongSingapore Institute for Clinical Sciences (SICS), A*STAR, Singapore 117609, Singapore.
Kothandaraman NarasimhanSingapore Institute for Clinical Sciences (SICS), A*STAR, Singapore 117609, Singapore.
Wei Fun CheongSingapore Lipidomics Incubator, Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117593, Singapore.
Sharon NgSingapore Institute for Clinical Sciences (SICS), A*STAR, Singapore 117609, Singapore.
Izzuddin M ArisDivision of Chronic Disease Research across the Lifecourse, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA 02215, USA.
See Ling LoyKK Women's and Children's Hospital (KKH), Singapore 229899, Singapore.
Anne K BendtSingapore Lipidomics Incubator, Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117593, Singapore.ORCID 0000-0001-8198-6104
Kok Hian TanKK Women's and Children's Hospital (KKH), Singapore 229899, Singapore.ORCID 0000-0003-1945-0266
Fabian K P YapKK Women's and Children's Hospital (KKH), Singapore 229899, Singapore.ORCID 0000-0003-1083-7958
Lynette P ShekSingapore Institute for Clinical Sciences (SICS), A*STAR, Singapore 117609, Singapore.ORCID 0000-0001-9064-8983
Yap Seng ChongSingapore Institute for Clinical Sciences (SICS), A*STAR, Singapore 117609, Singapore.
Peter D GluckmanSingapore Institute for Clinical Sciences (SICS), A*STAR, Singapore 117609, Singapore.
Keith M GodfreyMRC Lifecourse Epidemiology Centre, University of Southampton, University Hospital Southampton NHS Foundation Trust, Southampton SO16 6YD, UK.ORCID 0000-0002-4643-0618
Yung Seng LeeSingapore Institute for Clinical Sciences (SICS), A*STAR, Singapore 117609, Singapore.
Markus R WenkSingapore Lipidomics Incubator, Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117593, Singapore.
Neerja KarnaniSingapore Institute for Clinical Sciences (SICS), A*STAR, Singapore 117609, Singapore.
Shiao-Yng ChanSingapore Institute for Clinical Sciences (SICS), A*STAR, Singapore 117609, Singapore.ORCID 0000-0002-3530-3023
Agency for Science, Technology and Research · SGKK Women's and Children's Hospital · SGNational University of Singapore · SGHarvard University · USUniversity Hospital Southampton NHS Foundation Trust · GB

Funding

Life Sciences Institute, the National University of Singapore Yong Loo Lin School of Medicine Singapore Lipidomics IncubatorSingapore Institute for Clinical Sciences, Agency for Science Technology and Research (A*STAR) Human Development ProgrammeSingapore National Research Foundation NMRC/TCR/004-NUS/2008; NMRC/TCR/012-NUHS/2014; NRFI2015-05
6 · The paper itself

Abstract

Dysregulated transplacental lipid transfer and fetal-placental lipid metabolism affect birthweight, as does maternal hyperglycemia. As the mechanisms are unclear, we aimed to identify the lipids in umbilical cord plasma that were most associated with birthweight. Seventy-five Chinese women with singleton pregnancies recruited into the GUSTO mother-offspring cohort were selected from across the glycemic range based on a mid-gestation 75 g oral glucose tolerance test, excluding pre-existing diabetes. Cord plasma samples collected at term delivery were analyzed using targeted liquid-chromatography tandem mass-spectrometry to determine the concentrations of 404 lipid species across 17 lipid classes. The birthweights were standardized for sex and gestational age by local references, and regression analyses were adjusted for the maternal age, BMI, parity, mode of delivery, insulin treatment, and fasting/2 h glucose, with a false discovery-corrected

Indexed as

LysophospholipidsPlacentaBirth WeightFemaleHumansLysophosphatidylcholinesPregnancyUmbilical CordLysophosphatidylcholinesLysophospholipidsfetal growthGUSTOlipidomicslysophosphatidylcholinetriacylglycerolumbilical cord blood

Identifiers

PMID38257167
PMCPMC10820643
OpenAlexW4390948851

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.