Evidence map›Paper›PMID 38257115›Full record

Trial reportNutrients2024

Association of Glutamine and Glutamate Metabolism with Mortality among Patients at Nutritional Risk-A Secondary Analysis of the Randomized Clinical Trial EFFORT.

Carla Wunderle, Diana von Arx, Sydney Chiara Mueller, Luca Bernasconi, Peter Neyer, Pascal Tribolet, Zeno Stanga, Beat Mueller, Philipp Schuetz

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nutrients, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.2field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Glutamine metabolism in health and disease.Signal transduction and targeted therapy · 2026
    Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Carla WunderleDivision of General Internal and Emergency Medicine, University Department of Medicine, Kantonsspital Aarau, Tellstrasse 25, 5001 Aarau, Switzerland.ORCID 0000-0003-1720-6462
Diana von ArxMedical Faculty, University of Basel, 4056 Basel, Switzerland.
Sydney Chiara MuellerMedical Faculty, University of Basel, 4056 Basel, Switzerland.
Luca BernasconiInstitute of Laboratory Medicine, Kantonsspital Aarau, Tellstrasse 25, 5001 Aarau, Switzerland.
Peter NeyerInstitute of Laboratory Medicine, Kantonsspital Aarau, Tellstrasse 25, 5001 Aarau, Switzerland.ORCID 0000-0002-8682-9578
Pascal TriboletDivision of General Internal and Emergency Medicine, University Department of Medicine, Kantonsspital Aarau, Tellstrasse 25, 5001 Aarau, Switzerland.
Zeno StangaDepartment of Diabetes, Endocrinology, Nutritional Medicine and Metabolism (UDEM), Inselspital, Bern University Hospital, University of Bern, Freiburgstrasse 15, 3010 Bern, Switzerland.
Beat MuellerDivision of General Internal and Emergency Medicine, University Department of Medicine, Kantonsspital Aarau, Tellstrasse 25, 5001 Aarau, Switzerland.ORCID 0000-0002-1986-2511
Philipp SchuetzDivision of General Internal and Emergency Medicine, University Department of Medicine, Kantonsspital Aarau, Tellstrasse 25, 5001 Aarau, Switzerland.ORCID 0000-0001-6400-4949
Kantonsspital Aarau · CHUniversity of Basel · CHUniversity of Bern · CHUniversity of Vienna · AT

Funding

Swiss National Science Foundation PP00P3_150531Swiss National Science Foundation PP00P3_176972
6 · The paper itself

Abstract

Glutamine and its metabolite glutamate serve as the main energy substrates for immune cells, and their plasma levels drop during severe illness. Therefore, glutamine supplementation in the critical care setting has been advocated. However, little is known about glutamine metabolism in severely but not critically ill medical patients. We investigated the prognostic impact of glutamine metabolism in a secondary analysis of the

Indexed as

FrailtyMalnutritionCritical CareGlutamic AcidGlutamineHumansInpatientsGlutamic AcidGlutaminebiomarkerglutamateglutamineindividualized nutrition supportmalnutritionpolymorbid patient

Identifiers

PMID38257115
PMCPMC10821126
OpenAlexW4390695218

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.