SynthesisNutrients2024
Sex and Gender Differences on the Impact of Metabolism-Disrupting Chemicals on Obesity: A Systematic Review.
Synthesis in Nutrients, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 15 citations in OpenAlex.
- Sex- and gender-specific differences in treatment efficacy and safety of traditional Chinese medicine: a scoping review.Frontiers in global women's health · 2026Pooled it
- Effects of time-restricted eating on body composition and metabolic parameters in overweight and obese women: a systematic review and meta-analysis.Frontiers in nutrition · 2025Pooled it
- Subacute Exposure to Aldrin, Endosulfan and Lindane Differentially Alters Metabolic and Inflammatory Gene Expression in White and Brown Adipose Tissue of Male Rats.Cell biochemistry and function · 2026Article
- Chemical exposome patterns in mothers and children across urbanisation levels in five European birth cohorts.Journal of exposure science & environmental epidemiology · 2026Article
- Acetamiprid exerts sex-specific effects on adipose tissue of subjects with severe obesity.Frontiers in toxicology · 2026Article
- Dysregulation of hair-strand-based elemental biodynamics in amyotrophic lateral sclerosis.EBioMedicine · 2025Article
- Hair as an Indicator of Prolonged Paraben Exposure and Its Relation to Weight Gain in a Sample of Spanish Children: A Proof-of-Concept Study.Nutrients · 2025Article
- Trends in Metabolically Unhealthy Obesity by Age, Sex, Race/Ethnicity, and Income among United States Adults, 1999 to 2018.Diabetes & metabolism journal · 2025Article
- Analysis of inequities between demographic and social determinants associated with overweight and obesity.Revista brasileira de epidemiologia = Brazilian journal of epidemiology · 2025Article
- Global burden of polycystic ovary syndrome, uterine cancer and diabetes mellitus type 2 among women of childbearing age: trends in incidence, prevalence, mortality, and disability-adjusted life-years from 1990 to 2021.Frontiers in medicine · 2025Article
- Clustering of overweight and obese young adults based on their nutritional patterns and psychological state.Health psychology and behavioral medicine · 2025Article
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Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Obesity represents an important public health concern, being one of the leading causes of death worldwide. It is a multifactorial disease with many underlying intertwined causes, including genetic, environmental and behavioral factors. Notably, metabolism-disrupting chemicals (MDCs) can alter the set point control of metabolism, affecting the development and function of the adipose tissue. Epidemiological studies have reported associations between human exposure to MDCs and several altered metabolic endpoints. It is also noteworthy that sex and gender represent important risk factors in the development of obesity. Different sex-related biological and physiological characteristics influence individual susceptibility, whereas gender represents a critical component in determining the different exposure scenarios. Although some advancements in the treatment of obesity have been achieved in preclinical and clinical studies, the obesity pandemic continues to increase worldwide. The present study performed a systematic review of recent studies considering the effects of MDCs on obesity, with a specific focus on sex- and gender-related responses. This review highlighted that MDCs could differently affect men and women at different stages of life even though the number of studies evaluating the association between obesity and MDC exposure in relation to sex and gender is still limited. This evidence should urge researchers to carry out studies considering sex and gender differences. This is essential for developing sex-/gender-tailored prevention strategies to improve public health policies and reduce exposure.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.