Evidence map›Paper›PMID 38256943›Full record

ArticlePharmaceuticals (Basel, Switzerland)2024

Can Pharmacological Conditioning as an Add-On Treatment Optimize Standard Pharmacological Treatment in Patients with Recent-Onset Rheumatoid Arthritis? A Proof-of-Principle Randomized Clinical Trial.

Meriem Manaï, Henriët van Middendorp, Joy A van der Pol, Cornelia F Allaart, Elise Dusseldorp, Dieuwke S Veldhuijzen, Tom W J Huizinga, Andrea W M Evers

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 99% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Meriem ManaïHealth, Medical and Neuropsychology Unit, Leiden University, P.O. Box 9500, 2300 RA Leiden, The Netherlands.
Henriët van MiddendorpHealth, Medical and Neuropsychology Unit, Leiden University, P.O. Box 9500, 2300 RA Leiden, The Netherlands.ORCID 0000-0003-4575-0895
Joy A van der PolDepartment of Rheumatology, Leiden University Medical Center, P.O. Box 9600, 2300 RC Leiden, The Netherlands.ORCID 0000-0003-0721-9913
Cornelia F AllaartDepartment of Rheumatology, Leiden University Medical Center, P.O. Box 9600, 2300 RC Leiden, The Netherlands.
Elise DusseldorpMethodology and Statistics Unit, Leiden University, P.O. Box 9500, 2300 RA Leiden, The Netherlands.
Dieuwke S VeldhuijzenHealth, Medical and Neuropsychology Unit, Leiden University, P.O. Box 9500, 2300 RA Leiden, The Netherlands.
Tom W J HuizingaDepartment of Rheumatology, Leiden University Medical Center, P.O. Box 9600, 2300 RC Leiden, The Netherlands.
Andrea W M EversHealth, Medical and Neuropsychology Unit, Leiden University, P.O. Box 9500, 2300 RA Leiden, The Netherlands.
Leiden University · NLLeiden University Medical Center · NL

Funding

European Research Council ERC-2013-CoG-617700_EXPECTHEAL-TH
6 · The paper itself

Abstract

Medication regimens using conditioning via variable reinforcement have shown similar or improved therapeutic effects as full pharmacological treatment, but evidence in patient populations is scarce. This proof-of-principle double-blind randomized clinical trial examined whether treatment effects in recent-onset rheumatoid arthritis (RA) can be optimized through pharmacological conditioning. After four months of standardized treatment (

Indexed as

clinical remissionclinical trialpharmacological conditioningplacebo effectsrheumatoid arthritis

Identifiers

PMID38256943
PMCPMC10819065
OpenAlexW4390881690

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.