Evidence map›Paper›PMID 38256882›Full record

ArticlePharmaceuticals (Basel, Switzerland)2023

Protective Effect of Monoterpene Isoespintanol in a Rat Model of Prediabetes Induced by Fructose.

Luciana Di Sarli Gutiérrez, María Cecilia Castro, Sherley Farromeque Vásquez, Hernán Gonzalo Villagarcía, Luisa González Arbeláez, Benjamín Rojano, Guillermo Schinella, Bárbara Maiztegui, Flavio Francini

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.4field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Isoespintanol Isolated fromPlants (Basel, Switzerland) · 2025
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Luciana Di Sarli GutiérrezCENEXA (Centre for Experimental and Applied Endocrinology, UNLP CONICET CCT La Plata, CEAS CICPBA), School of Medicine, Street 60 and 120, La Plata 1900, Argentina.
María Cecilia CastroCENEXA (Centre for Experimental and Applied Endocrinology, UNLP CONICET CCT La Plata, CEAS CICPBA), School of Medicine, Street 60 and 120, La Plata 1900, Argentina.
Sherley Farromeque VásquezCENEXA (Centre for Experimental and Applied Endocrinology, UNLP CONICET CCT La Plata, CEAS CICPBA), School of Medicine, Street 60 and 120, La Plata 1900, Argentina.
Hernán Gonzalo VillagarcíaCENEXA (Centre for Experimental and Applied Endocrinology, UNLP CONICET CCT La Plata, CEAS CICPBA), School of Medicine, Street 60 and 120, La Plata 1900, Argentina.
Luisa González ArbeláezCIC (Centre for Cardiovascular Research, UNLP CONICET CCT La Plata), School of Medicine, Street 60 and 120, La Plata 1900, Argentina.
Benjamín RojanoFood Science Laboratory, Faculty of Sciences, National University of Colombia, Medellín Campus, Medellin 050034, Colombia.
Guillermo SchinellaSchool of Medicine, UNLP, Street 60 and 120, La Plata 1900, Argentina.ORCID 0000-0001-9541-9688
Bárbara MaizteguiCENEXA (Centre for Experimental and Applied Endocrinology, UNLP CONICET CCT La Plata, CEAS CICPBA), School of Medicine, Street 60 and 120, La Plata 1900, Argentina.ORCID 0000-0002-9871-943X
Flavio FranciniCENEXA (Centre for Experimental and Applied Endocrinology, UNLP CONICET CCT La Plata, CEAS CICPBA), School of Medicine, Street 60 and 120, La Plata 1900, Argentina.ORCID 0000-0001-6197-7251
Consejo Nacional de Investigaciones Científicas y Técnicas · ARUniversidad Nacional de Colombia · COUniversidad Nacional de La Plata · AR

Funding

Consejo Nacional de Investigaciones Científicas y Técnicas CONICET (PIP-2021/2023)FONCYT PICT2021CAT-II-00070National University of La Plata M-231
6 · The paper itself

Abstract

A high-fructose diet (HFD) induces murine alterations like those recorded in human prediabetes. Protective effects of isoespintanol (monoterpene isolated from Oxandra cf. xylopioides) on changes induced by HFD were evaluated. Animals were maintained for 21 days with a standard diet (C), 10% fructose (F), and F plus isoespintanol (FI, 10 mg/kg, i.p.). Glycemia, triglyceridemia, total and HDL-cholesterol, and insulin resistance index (IRX) were determined. Intraperitoneal glucose tolerance test (IGTT) was performed. In the liver, we measured glycogen, lipogenic gene expression (

Indexed as

hepatic lipogenesisinflammationisoespintanoloxidative stressprediabetes

Identifiers

PMID38256882
PMCPMC10819293
OpenAlexW4390347765

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.