Evidence map›Paper›PMID 38256865›Full record

ArticlePharmaceuticals (Basel, Switzerland)2023

Synthesis and Biological Evaluation of Chalconesulfonamides: En Route to Proapoptotic Agents with Antiestrogenic Potency.

Stepan K Krymov, Diana I Salnikova, Lyubov G Dezhenkova, Fedor B Bogdanov, Alexander A Korlyukov, Alexander M Scherbakov, Andrey E Shchekotikhin

Abstract read
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Stepan K KrymovGause Institute of New Antibiotics, 11 B. Pirogovskaya Street, 119021 Moscow, Russia.ORCID 0000-0002-8367-9500
Diana I SalnikovaDepartment of Experimental Tumor Biology, Blokhin N. N. National Medical Research Center of Oncology, Kashirskoe sh. 24, 115522 Moscow, Russia.ORCID 0000-0002-0809-3710
Lyubov G DezhenkovaGause Institute of New Antibiotics, 11 B. Pirogovskaya Street, 119021 Moscow, Russia.
Fedor B BogdanovDepartment of Experimental Tumor Biology, Blokhin N. N. National Medical Research Center of Oncology, Kashirskoe sh. 24, 115522 Moscow, Russia.ORCID 0000-0002-0976-0335
Alexander A KorlyukovA. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, Vavilov Str. 28, 119334 Moscow, Russia.
Alexander M ScherbakovDepartment of Experimental Tumor Biology, Blokhin N. N. National Medical Research Center of Oncology, Kashirskoe sh. 24, 115522 Moscow, Russia.ORCID 0000-0002-2974-9555
Andrey E ShchekotikhinGause Institute of New Antibiotics, 11 B. Pirogovskaya Street, 119021 Moscow, Russia.ORCID 0000-0002-6595-0811

Funding

Russian Science Foundation 20-13-00402-P
6 · The paper itself

Abstract

Breast and other estrogen receptor α-positive cancers tend to develop resistance to existing drugs. Chalcone derivatives possess anticancer activity based on their ability to form covalent bonds with targets acting as Michael acceptors. This study aimed to evaluate the anticancer properties of a series of chalcones (

Indexed as

4-hydroxytamoxifen resistanceantiproliferative activitybreast cancerchalconeestrogen receptor αsulfonamide

Identifiers

PMID38256865
PMCPMC10818622

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.