Evidence map›Paper›PMID 38256502›Full record

ArticleJournal of clinical medicine2024

Amyloid Burden Correlates with Electrocardiographic Findings in Patients with Cardiac Amyloidosis-Insights from Histology and Cardiac Magnetic Resonance Imaging.

Franz Duca, René Rettl, Christina Kronberger, Michael Poledniczek, Christina Binder, Daniel Dalos, Matthias Koschutnik, Carolina Donà, Dietrich Beitzke, Christian Loewe and 6 more

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 2 pooled it
1.9field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 2 syntheses or guidelines pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Mechanisms of damage and therapies for cardiac amyloidosis: a role for inflammation?Clinical research in cardiology : official journal of the German Cardiac Society · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 1 institution in 1 country.

Franz DucaDivision of Cardiology, Department of Internal Medicine II, Medical University of Vienna, 1090 Vienna, Austria.ORCID 0000-0002-7519-5274
René RettlDivision of Cardiology, Department of Internal Medicine II, Medical University of Vienna, 1090 Vienna, Austria.ORCID 0000-0001-6409-5158
Christina KronbergerDivision of Cardiology, Department of Internal Medicine II, Medical University of Vienna, 1090 Vienna, Austria.ORCID 0000-0002-3866-3710
Michael PoledniczekDivision of Cardiology, Department of Internal Medicine II, Medical University of Vienna, 1090 Vienna, Austria.ORCID 0000-0002-6091-9823
Christina BinderDivision of Cardiology, Department of Internal Medicine II, Medical University of Vienna, 1090 Vienna, Austria.ORCID 0000-0001-6060-7910
Daniel DalosDivision of Cardiology, Department of Internal Medicine II, Medical University of Vienna, 1090 Vienna, Austria.ORCID 0000-0002-9597-5745
Matthias KoschutnikDivision of Cardiology, Department of Internal Medicine II, Medical University of Vienna, 1090 Vienna, Austria.ORCID 0000-0001-6164-8773
Carolina DonàDivision of Cardiology, Department of Internal Medicine II, Medical University of Vienna, 1090 Vienna, Austria.
Dietrich BeitzkeDivision of Cardiovascular and Interventional Radiology, Department of Bioimaging and Image-Guided Therapy, Medical University of Vienna, 1090 Vienna, Austria.ORCID 0000-0003-3179-3827
Christian LoeweDivision of Cardiovascular and Interventional Radiology, Department of Bioimaging and Image-Guided Therapy, Medical University of Vienna, 1090 Vienna, Austria.
Christian NitscheDivision of Cardiology, Department of Internal Medicine II, Medical University of Vienna, 1090 Vienna, Austria.ORCID 0000-0002-0141-7639
Christian HengstenbergDivision of Cardiology, Department of Internal Medicine II, Medical University of Vienna, 1090 Vienna, Austria.ORCID 0000-0002-8284-2994
Roza Badr-EslamDivision of Cardiology, Department of Internal Medicine II, Medical University of Vienna, 1090 Vienna, Austria.
Johannes KastnerDivision of Cardiology, Department of Internal Medicine II, Medical University of Vienna, 1090 Vienna, Austria.
Jutta Bergler-KleinDivision of Cardiology, Department of Internal Medicine II, Medical University of Vienna, 1090 Vienna, Austria.
Andreas Anselm KammerlanderDivision of Cardiology, Department of Internal Medicine II, Medical University of Vienna, 1090 Vienna, Austria.ORCID 0000-0002-7632-9879
Medical University of Vienna · AT

Funding

Pfizer Austria not applicable
6 · The paper itself

Abstract

Cardiac amyloidosis (CA) is associated with several distinct electrocardiographic (ECG) changes. However, the impact of amyloid depositions on ECG parameters is not well investigated. We therefore aimed to assess the correlation of amyloid burden with ECG and test the prognostic power of ECG findings on outcomes in patients with CA. Consecutive CA patients underwent ECG assessment and cardiac magnetic resonance imaging (CMR), including the quantification of extracellular volume (ECV) with T1 mapping. Moreover, seven patients underwent additional amyloid quantification using immunohistochemistry staining of endomyocardial biopsies. A total of 105 CA patients (wild-type transthyretin: 74.3%, variant transthyretin: 8.6%, light chain: 17.1%) were analyzed for this study. We detected correlations of total QRS voltage with histologically quantified amyloid burden (r = -0.780,

Indexed as

cardiac amyloidosiscardiac magnetic resonance imagingelectrocardiogramextracellular volumehistologylight chain amyloidosisT1 mappingtransthyretin amyloidosis

Identifiers

PMID38256502
PMCPMC10816127
OpenAlexW4390769467

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.