ReviewJournal of clinical medicine2024
Investigating the Association of Assisted Reproduction Techniques and Adverse Perinatal Outcomes.
Review in Journal of clinical medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 17 citations in OpenAlex.
- Antenatally diagnosed severe congenital pulmonary airway malformation requiring life-saving lobectomy in the early neonatal period: A case report.Radiology case reports · 2026Article
- Relationship Between Sperm DNA Fragmentation and Composite Morphological Indices: A Multivariable Analysis.Medicina (Kaunas, Lithuania) · 2026Observational
- Induction of Stress Granules and Developmental Instability of Offspring Phenotype Due to Hypothermia During First Mouse Embryo Cleavage.International journal of molecular sciences · 2025Article
- Immunological Factors in Recurrent Pregnancy Loss: Mechanisms, Controversies, and Emerging Therapies.Biology · 2025Review
- Mass Spectrometry-Based Untargeted Metabolomics Identifies Distinct Metabolic Signatures in Infertility: A Comparative Analysis of PCOS, POR, and NOR.Reproductive sciences (Thousand Oaks, Calif.) · 2025Article
- Metabolomics-Driven Insights into Biomarkers for Poor Ovarian Response: A Narrative Review.Biomedicines · 2025Review
- Oxidative Stress and the NLRP3 Inflammasome: Focus on Female Fertility and Reproductive Health.Cells · 2025Review
- Article
- The Effect of Bisphenol and Its Cytotoxicity on Female Infertility and Pregnancy Outcomes: A Narrative Review.Journal of clinical medicine · 2024Review
- Assisted reproductive technology and the risk of fetal congenital heart disease: insights from a tertiary-care referral center.Archives of gynecology and obstetrics · 2024Article
- Sperm DNA Fragmentation: Unraveling Its Imperative Impact on Male Infertility Based on Recent Evidence.International journal of molecular sciences · 2024Review
- The Expression of microRNAs and Their Involvement in Recurrent Pregnancy Loss.Journal of clinical medicine · 2024Review
- Assisted Reproductive Technologies: A New Player in the Foetal Programming of Childhood and Adult Diseases?Pediatric reports · 2024Review
- The Contribution of Proteomics in Understanding Endometrial Protein Expression in Women with Recurrent Implantation Failure.Journal of clinical medicine · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundInfertility affects about 80 million individuals worldwide and 10-15% of couples at reproductive age will seek medical assistance. There is increasing evidence that pregnancies after Assisted Reproduction Techniques (ART) are associated with pre-term birth, low birthweight, congenital defects, and increased mortality rates. The aim of this review is to assess all the published literature and provide an updated review on the effect of assisted conception and perinatal and neonatal outcomes.
methodsComprehensive research on Pubmed/Medline, Scopus, and Google scholar electronic databases was conducted from July 2023 up to September 2023, using the terms assisted reproductive techniques, ART, in vitro fertilization, IVF, intracytoplasmic sperm injection, ICSI, preterm birth, PTB, low birth weight, LBW, chromosomal defects, congenital defects, and hypospadias. In total, 87 full text articles were retrieved and after a careful evaluation, 31 studies were selected for data extraction.
resultsOur review demonstrated a higher risk of congenital and chromosomal defects, and a higher incidence of male genital tract defects and heart defects in ART pregnancies. Regarding pre-term birth, our results were contradictory.
conclusionsAlthough assisted reproduction techniques are associated with increased risks, they are safe regarding perinatal outcomes and couples should not be discouraged from utilizing them. Our results aim to alert clinicians to these specific outcomes and offer more personalized care and counseling to infertile couples and their children.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.