Evidence map›Paper›PMID 38256225›Full record

SynthesisInternational journal of molecular sciences2024

Bioactive-Glass-Based Materials with Possible Application in Diabetic Wound Healing: A Systematic Review.

Marian Vargas Guerrero, Floor M A Aendekerk, Candice de Boer, Jan Geurts, Jimmy Lucchesi, Jacobus J C Arts

Open access · goldAbstract readSystematic Review
In one paragraph

Synthesis in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Review
  6. Applications and prospects of biomaterials in diabetes management.Frontiers in bioengineering and biotechnology · 2025
    Review
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Marian Vargas GuerreroDepartment of Orthopaedic Surgery, Maastricht University Medical Centre (MUMC+), 6229 HX Maastricht, The Netherlands.
Floor M A AendekerkDepartment of Orthopaedic Surgery, Maastricht University Medical Centre (MUMC+), 6229 HX Maastricht, The Netherlands.ORCID 0009-0003-0446-3002
Candice de BoerDepartment of Orthopaedic Surgery, Maastricht University Medical Centre (MUMC+), 6229 HX Maastricht, The Netherlands.
Jan GeurtsDepartment of Orthopaedic Surgery, Maastricht University Medical Centre (MUMC+), 6229 HX Maastricht, The Netherlands.ORCID 0000-0002-0973-572X
Jimmy LucchesiBonalive Biomaterials, 20750 Turku, Finland.
Jacobus J C ArtsDepartment of Orthopaedic Surgery, Maastricht University Medical Centre (MUMC+), 6229 HX Maastricht, The Netherlands.
Maastricht University Medical Centre · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetes affected 537 million adults in 2021, costing a total of USD 966 billion dollars in healthcare. One of the most common complications associated with diabetes corresponds to the development of diabetic foot ulcers (DFUs). DFUs affect around 15% of diabetic patients; these ulcers have impaired healing due to neuropathy, arterial disease, infection, and aberrant extracellular matrix (ECM) degradation, among other factors. The bioactive-glass-based materials discussed in this systematic review show promising results in accelerating diabetic wound healing. It can be concluded that the addition of BG is extremely valuable with regard to the wound healing rate and wound healing quality, since BG activates fibroblasts, enhances M1-to-M2 phenotype switching, induces angiogenesis, and initiates the formation of granulation tissue and re-epithelization of the wound. In addition, a higher density and deposition and better organization of collagen type III are seen. This systematic review was made using the PRISMA guideline and intends to contribute to the advancement of diabetic wound healing therapeutic strategies development by providing an overview of the materials currently being developed and their effect in diabetic wound healing in vitro and in vivo.

Indexed as

Diabetes MellitusDiabetic FootAdultCollagen Type IIIFibroblastsGranulation TissueHumansWound HealingCollagen Type IIIangiogenesisbioactive glassdiabetic woundsosteomyelitiswound healing

Identifiers

PMID38256225
PMCPMC10816070
OpenAlexW4390985214

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.