Evidence map›Paper›PMID 38256217›Full record

ArticleInternational journal of molecular sciences2024

The Role of Key Amino Acids of the Human Fe(II)/2OG-Dependent Dioxygenase ALKBH3 in Structural Dynamics and Repair Activity toward Methylated DNA.

Lyubov Yu Kanazhevskaya, Alexey A Gorbunov, Maria V Lukina, Denis A Smyshliaev, Polina V Zhdanova, Alexander A Lomzov, Vladimir V Koval

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 64% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Lyubov Yu KanazhevskayaInstitute of Chemical Biology and Fundamental Medicine (ICBFM), 8 Lavrentiev Ave., Novosibirsk 630090, Russia.ORCID 0000-0001-6832-2522
Alexey A GorbunovInstitute of Chemical Biology and Fundamental Medicine (ICBFM), 8 Lavrentiev Ave., Novosibirsk 630090, Russia.ORCID 0009-0005-5502-9681
Maria V LukinaInstitute of Chemical Biology and Fundamental Medicine (ICBFM), 8 Lavrentiev Ave., Novosibirsk 630090, Russia.
Denis A SmyshliaevInstitute of Chemical Biology and Fundamental Medicine (ICBFM), 8 Lavrentiev Ave., Novosibirsk 630090, Russia.
Polina V ZhdanovaInstitute of Chemical Biology and Fundamental Medicine (ICBFM), 8 Lavrentiev Ave., Novosibirsk 630090, Russia.ORCID 0000-0003-0695-6698
Alexander A LomzovInstitute of Chemical Biology and Fundamental Medicine (ICBFM), 8 Lavrentiev Ave., Novosibirsk 630090, Russia.ORCID 0000-0003-3889-9464
Vladimir V KovalInstitute of Chemical Biology and Fundamental Medicine (ICBFM), 8 Lavrentiev Ave., Novosibirsk 630090, Russia.ORCID 0000-0002-2577-2184
Novosibirsk State University · RUInstitute of Chemical Biology and Fundamental Medicine · RU

Funding

Russian Science Foundation 22-24-00699
6 · The paper itself

Abstract

Non-heme dioxygenases of the AlkB family hold a unique position among enzymes that repair alkyl lesions in nucleic acids. These enzymes activate the Fe(II) ion and molecular oxygen through the coupled decarboxylation of the 2-oxoglutarate co-substrate to subsequently oxidize the substrate. ALKBH3 is a human homolog of

Indexed as

AlkB Homolog 3, Alpha-Ketoglutarate-Dependent DioxygenaseDNA MethylationAmino AcidsDNAFerrous CompoundsHumansALKBH3 protein, humanAlkB Homolog 3, Alpha-Ketoglutarate-Dependent DioxygenaseAmino AcidsDNAFerrous Compoundscircular dichroismconformational dynamicsdioxygenase ALKBH3DNA methylationDNA repairfluorescent spectroscopysite-directed mutagenesisstopped-flow method

Identifiers

PMID38256217
PMCPMC10816986
OpenAlexW4390942303

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.