Evidence map›Paper›PMID 38256106›Full record

ArticleInternational journal of molecular sciences2024

Exposure to Secondhand Smoke Extract Increases Cisplatin Resistance in Head and Neck Cancer Cells.

Balaji Sadhasivam, Jimmy Manyanga, Vengatesh Ganapathy, Pawan Acharya, Célia Bouharati, Mayilvanan Chinnaiyan, Toral Mehta, Basil Mathews, Samuel Castles, David A Rubenstein and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. E-Cigarette effects on oral health: A molecular perspective.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2025
    Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 2 countries.

Balaji SadhasivamDepartment of Otolaryngology Head and Neck Surgery, The University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.ORCID 0000-0002-3207-4392
Jimmy ManyangaDepartment of Otolaryngology Head and Neck Surgery, The University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
Vengatesh GanapathyDepartment of Otolaryngology Head and Neck Surgery, The University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.ORCID 0000-0002-1662-4921
Pawan AcharyaDepartment of Biostatistics, The University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
Célia BouharatiDepartment of Otolaryngology Head and Neck Surgery, The University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
Mayilvanan ChinnaiyanDepartment of Otolaryngology Head and Neck Surgery, The University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
Toral MehtaDepartment of Otolaryngology Head and Neck Surgery, The University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.ORCID 0000-0002-3922-8059
Basil MathewsDepartment of Otolaryngology Head and Neck Surgery, The University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
Samuel CastlesDepartment of Otolaryngology Head and Neck Surgery, The University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
David A RubensteinDepartment of Biomedical Engineering, Stony Brook University, New York City, NY 11794, USA.
Alayna P TackettTSET Health Promotion Research Center, Stephenson Cancer Center, The University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
Yan D ZhaoDepartment of Biostatistics, The University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
Ilangovan RamachandranDepartment of Endocrinology, Dr. ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai, TN 600113, India.
Lurdes QueimadoDepartment of Otolaryngology Head and Neck Surgery, The University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.ORCID 0000-0002-1106-4873
University of Oklahoma Health Sciences Center · USStony Brook University · USUniversity of Madras · IN

Funding

Tissue Pathology Shared ResourceP30CA225520 · NCI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI ROBERT S. MANNEL · 2018 to 2026
$27.1M
Biological impact of exclusive and dual e-cigarette use on oral cancer riskR01CA242168 · NCI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI QUEIMADO, LURDES · 2020 to 2024
$2.2M
A novel molecular assay for early detection and assessment of cancer riskR33CA202898 · NCI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI QUEIMADO, LURDES · 2016 to 2018
$1.0M
NCI NIH HHS P30 CA225520NCI NIH HHS P30CA225520NCI NIH HHS R01 CA242168NCI NIH HHS R01CA242168NCI NIH HHS R33 CA202898NCI NIH HHS R33CA202898
6 · The paper itself

Abstract

Chemotherapy and radiotherapy resistance are major obstacles in the long-term efficacy of head and neck squamous cell carcinoma (HNSCC) treatment. Secondhand smoke (SHS) exposure is common and has been proposed as an independent predictor of HNSCC recurrence and disease-free survival. However, the underlying mechanisms responsible for these negative patient outcomes are unknown. To assess the effects of SHS exposure on cisplatin efficacy in cancer cells, three distinct HNSCC cell lines were exposed to sidestream (SS) smoke, the main component of SHS, at concentrations mimicking the nicotine level seen in passive smokers' saliva and treated with cisplatin (0.01-100 µM) for 48 h. Compared to cisplatin treatment alone, cancer cells exposed to both cisplatin and SS smoke extract showed significantly lower cisplatin-induced cell death and higher cell viability, IC

Indexed as

Head and Neck NeoplasmsTobacco Smoke PollutionCell DeathCisplatinHumansSquamous Cell Carcinoma of Head and NeckCisplatinTobacco Smoke Pollutioncell deathcisplatinhead and neck squamous cell carcinoma (HNSCC)IC50multidrug resistanceoral cancerresponse to therapysecondhand smoke

Identifiers

PMID38256106
PMCPMC10816441
OpenAlexW4390882002

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.