Rats Selected for Different Nervous Excitability: Long-Term Emotional-Painful Stress Affects the Dynamics of DNA Damage in Cells of Several Brain Areas.

Veronika Shcherbinina, Marina Pavlova, Eugene Daev, Natalia Dyuzhikova

Open access · goldAbstract read

In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

0.3field-weighted citation impact, top 53% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Veronika ShcherbininaLaboratory of Higher Nervous Activity Genetics, Pavlov Institute of Physiology, Russian Academy of Sciences, nab. Makarova, 6, 199034 Saint Petersburg, Russia.ORCID 0000-0002-4813-736X

Marina PavlovaLaboratory of Higher Nervous Activity Genetics, Pavlov Institute of Physiology, Russian Academy of Sciences, nab. Makarova, 6, 199034 Saint Petersburg, Russia.

Eugene DaevLaboratory of Higher Nervous Activity Genetics, Pavlov Institute of Physiology, Russian Academy of Sciences, nab. Makarova, 6, 199034 Saint Petersburg, Russia.ORCID 0000-0003-2036-6790

Natalia DyuzhikovaLaboratory of Higher Nervous Activity Genetics, Pavlov Institute of Physiology, Russian Academy of Sciences, nab. Makarova, 6, 199034 Saint Petersburg, Russia.

Pavlov Institute of Physiology of the Russian Academy of Sciences · RUSt Petersburg University · RU

Funding

State Program 47 "Scientific and Technological Development of the Russian Federation" (2019-2030) theme reg. no. 0134-2019-0002

6 · The paper itself

Abstract

The maintenance of genome stability is critical for health, but during individual ontogenesis, different stressors affect DNA integrity, which can lead to functional and/or structural changes in the cells of target organs. In the nervous system, cell genome destabilization is associated with different neurological and psychiatric diseases, but experiments in vivo, where a link between stress and DNA instability has been demonstrated, are relatively rare. Here, we use rat strains selected for the contrast excitability of the tibialis nerve (

Indexed as

BrainStress Disorders, Post-TraumaticAnimalsDNADNA DamagePainRatsRats, WistarDNAamygdalacomet assaycompulsive disorderDNA damagehippocampusnervous system excitabilityprefrontal cortexPTSDratsstress

Identifiers

PMID38256068

DOI10.3390/ijms25020994

PMCPMC10815859

OpenAlexW4390876947

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.