Evidence map›Paper›PMID 38256033›Full record

ReviewInternational journal of molecular sciences2024

PAMPs and DAMPs in Sepsis: A Review of Their Molecular Features and Potential Clinical Implications.

Sara Cicchinelli, Giulia Pignataro, Stefania Gemma, Andrea Piccioni, Domitilla Picozzi, Veronica Ojetti, Francesco Franceschi, Marcello Candelli

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 86 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
86citing papers in PubMed, 1 pooled it
18.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

86 citing papers in PubMed, 1 synthesis or guideline pooled it, 77 citations in OpenAlex.

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  20. Current issues in molecular biology · 2026
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26 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Sara CicchinelliDepartment of Emergency, S.S. Filippo e Nicola Hospital, 67051 Avezzano, Italy.
Giulia PignataroDepartment of Emergency, Anesthesiological and Reanimation Sciences, Fondazione Policlinico Universitario Agostino Gemelli-IRRCS, Università Cattolica del Sacro Cuore, 00168 Roma, Italy.
Stefania GemmaDepartment of Emergency, Anesthesiological and Reanimation Sciences, Fondazione Policlinico Universitario Agostino Gemelli-IRRCS, Università Cattolica del Sacro Cuore, 00168 Roma, Italy.ORCID 0009-0001-5471-5285
Andrea PiccioniDepartment of Emergency, Anesthesiological and Reanimation Sciences, Fondazione Policlinico Universitario Agostino Gemelli-IRRCS, Università Cattolica del Sacro Cuore, 00168 Roma, Italy.ORCID 0000-0001-5703-8737
Domitilla PicozziDepartment of Emergency, Anesthesiological and Reanimation Sciences, Fondazione Policlinico Universitario Agostino Gemelli-IRRCS, Università Cattolica del Sacro Cuore, 00168 Roma, Italy.ORCID 0009-0008-5006-5562
Veronica OjettiDepartment of Emergency, Anesthesiological and Reanimation Sciences, Fondazione Policlinico Universitario Agostino Gemelli-IRRCS, Università Cattolica del Sacro Cuore, 00168 Roma, Italy.
Francesco FranceschiDepartment of Emergency, Anesthesiological and Reanimation Sciences, Fondazione Policlinico Universitario Agostino Gemelli-IRRCS, Università Cattolica del Sacro Cuore, 00168 Roma, Italy.
Marcello CandelliDepartment of Emergency, Anesthesiological and Reanimation Sciences, Fondazione Policlinico Universitario Agostino Gemelli-IRRCS, Università Cattolica del Sacro Cuore, 00168 Roma, Italy.ORCID 0000-0001-8443-7880
Università Cattolica del Sacro Cuore · ITOspedale San Filippo Neri · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sepsis is a serious organ dysfunction caused by a dysregulated immune host reaction to a pathogen. The innate immunity is programmed to react immediately to conserved molecules, released by the pathogens (PAMPs), and the host (DAMPs). We aimed to review the molecular mechanisms of the early phases of sepsis, focusing on PAMPs, DAMPs, and their related pathways, to identify potential biomarkers. We included studies published in English and searched on PubMed

Indexed as

Pathogen-Associated Molecular Pattern MoleculesSepsisAlarminsHumansImmunity, InnatePubMedAlarminsPathogen-Associated Molecular Pattern MoleculesDAMPsinnate immunityPAMPssepsisseptic shock

Identifiers

PMID38256033
PMCPMC10815927
OpenAlexW4390823737

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.