Evidence map›Paper›PMID 38255953›Full record

ArticleInternational journal of molecular sciences2024

HLA Polymorphisms and Clinical Manifestations in IgA Vasculitis.

Martina Held, Katarina Stingl Jankovic, Mario Sestan, Matej Sapina, Nastasia Kifer, Sasa Srsen, Marijan Frkovic, Alenka Gagro, Zorana Grubic, Marija Jelusic

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Martina HeldDepartment of Pediatrics, University Hospital Centre Zagreb, University of Zagreb School of Medicine, 10000 Zagreb, Croatia.ORCID 0000-0002-4925-8948
Katarina Stingl JankovicTissue Typing Centre, Clinical Department for Transfusion Medicine and Transplantation Biology, University Hospital Centre Zagreb, 10000 Zagreb, Croatia.
Mario SestanDepartment of Pediatrics, University Hospital Centre Zagreb, University of Zagreb School of Medicine, 10000 Zagreb, Croatia.ORCID 0000-0003-1092-6491
Matej SapinaDepartment of Pediatrics, University Hospital Centre Osijek, Josip Juraj Strossmayer University of Osijek, Medical Faculty Osijek, 31000 Osijek, Croatia.
Nastasia KiferDepartment of Pediatrics, University Hospital Centre Zagreb, University of Zagreb School of Medicine, 10000 Zagreb, Croatia.
Sasa SrsenDepartment of Pediatrics, University of Split School of Medicine, University Hospital Centre Split, 21000 Split, Croatia.ORCID 0000-0001-6555-2613
Marijan FrkovicDepartment of Pediatrics, University Hospital Centre Zagreb, University of Zagreb School of Medicine, 10000 Zagreb, Croatia.ORCID 0000-0002-1520-3375
Alenka GagroChildren's Hospital Zagreb, Medical Faculty Osijek, Josip Juraj Strossmayer University of Osijek, 10000 Zagreb, Croatia.
Zorana GrubicTissue Typing Centre, Clinical Department for Transfusion Medicine and Transplantation Biology, University Hospital Centre Zagreb, 10000 Zagreb, Croatia.
Marija JelusicDepartment of Pediatrics, University Hospital Centre Zagreb, University of Zagreb School of Medicine, 10000 Zagreb, Croatia.ORCID 0000-0002-1728-4260

Funding

Croatian Science Foundation IP-2019-04-8822
6 · The paper itself

Abstract

Studies concerning the genetic background of IgA vasculitis (IgAV), a small-vessel vasculitis occurring predominantly in childhood, have confirmed that the HLA-DRB1 gene showed a strong association with disease susceptibility. The objective was to investigate human leukocyte antigen (HLA) polymorphisms among Croatian patients with IgAV and their influence on disease susceptibility and clinical heterogeneity. Thus, 130 children with IgAV and 202 unrelated healthy individuals were enrolled in the study. Genomic DNA was extracted from whole peripheral blood, and HLA-A, -B, -DRB1 and -DQB1 gene polymorphism analysis was performed. HLA-A*03 (21.4% vs. 12.38%,

Indexed as

Genetic Predisposition to DiseaseHLA AntigensIgA VasculitisChildHLA-A AntigensHLA-B AntigensHLA-DRB1 ChainsHumansHLA-A AntigensHLA AntigensHLA-B AntigensHLA-DRB1 Chainsallele frequenciesCroatianshigh-resolution typingHLA-DRB1human leukocyte antigen polymorphismsIgA vasculitisnext generation sequencing

Identifiers

PMID38255953
PMCPMC10815612

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.