Evidence map›Paper›PMID 38255930›Full record

ArticleInternational journal of molecular sciences2024

Expression of Elafin and CD200 as Immune Checkpoint Molecules Involved in Celiac Disease.

Candelaria Ponce-de-León, Pedro Lorite, Miguel Ángel López-Casado, Pablo Mora, Teresa Palomeque, María Isabel Torres

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Candelaria Ponce-de-LeónDepartment of Experimental Biology, Faculty of Health Sciences, University of Jaén, 23071 Jaén, Spain.
Pedro LoriteDepartment of Experimental Biology, Faculty of Health Sciences, University of Jaén, 23071 Jaén, Spain.ORCID 0000-0002-9692-5870
Miguel Ángel López-CasadoDepartment of Pediatric Gastroenterology, Virgen de las Nieves Hospital, 18014 Granada, Spain.
Pablo MoraDepartment of Experimental Biology, Faculty of Health Sciences, University of Jaén, 23071 Jaén, Spain.ORCID 0000-0001-7967-3379
Teresa PalomequeDepartment of Experimental Biology, Faculty of Health Sciences, University of Jaén, 23071 Jaén, Spain.ORCID 0000-0002-7144-4931
María Isabel TorresDepartment of Experimental Biology, Faculty of Health Sciences, University of Jaén, 23071 Jaén, Spain.ORCID 0000-0002-9309-3837
Universidad de Jaén · ESHospital Universitario Virgen de las Nieves · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We comprehensively evaluated the expression of therapeutically targetable immune checkpoint molecules involved in celiac disease (CD). We have focused on the alteration of the CD200/CD200R pathway and Elafin expression in celiac disease and discussed their roles in regulating the immune response. There are limited data related to the expression or function of these molecules in celiac disease. This finding could significantly contribute to the understanding of the clinical manifestation of CD. CD200, CD200R and Elafin distributions were determined by ELISA and immunohistochemistry analyses in serum and biopsies of CD patients. Analyses of Th1 and Th17 cytokines were determined. PCR amplification of a fragment of the

Indexed as

Celiac DiseaseImmune Checkpoint ProteinsCytokinesElafinGenotypeHumansCytokinesElafinImmune Checkpoint ProteinsCD200/CD200Rceliac diseaseElafingluten peptidesimmune checkpoint

Identifiers

PMID38255930
PMCPMC10815464
OpenAlexW4390695503

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.