Evidence map›Paper›PMID 38255924›Full record

ArticleInternational journal of molecular sciences2024

Classification of MLH1 Missense VUS Using Protein Structure-Based Deep Learning-Ramachandran Plot-Molecular Dynamics Simulations Method.

Benjamin Tam, Zixin Qin, Bojin Zhao, Siddharth Sinha, Chon Lok Lei, San Ming Wang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.9field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Benjamin TamMinistry of Education Frontiers Science Center for Precision Oncology, Faculty of Health Sciences, University of Macau, Macau SAR, China.ORCID 0000-0002-8119-3996
Zixin QinMinistry of Education Frontiers Science Center for Precision Oncology, Faculty of Health Sciences, University of Macau, Macau SAR, China.
Bojin ZhaoMinistry of Education Frontiers Science Center for Precision Oncology, Faculty of Health Sciences, University of Macau, Macau SAR, China.
Siddharth SinhaMinistry of Education Frontiers Science Center for Precision Oncology, Faculty of Health Sciences, University of Macau, Macau SAR, China.ORCID 0000-0003-3868-1967
Chon Lok LeiMinistry of Education Frontiers Science Center for Precision Oncology, Faculty of Health Sciences, University of Macau, Macau SAR, China.ORCID 0000-0003-0904-554X
San Ming WangMinistry of Education Frontiers Science Center for Precision Oncology, Faculty of Health Sciences, University of Macau, Macau SAR, China.ORCID 0000-0002-2172-1320
University of Macau · MO

Funding

Postdoctoral Fellowship of Macau Science and Technology Development Fund UMMTP-FDCT/0027/APD/2021The Faculty of Health Sciences of University of Macau FHS-CC-041-001-2023The Faculty of Health Sciences of University of Macau FHSIG/SW/0007/2020PThe Faculty of Health Sciences of University of Macau FHS Innovation grantThe Faculty of Health Sciences of University of Macau Startup fundthe Macau Science and Technology Development Fund 0032-2022-A1the Macau Science and Technology Development Fund 0077/2019/AMJthe Macau Science and Technology Development Fund 085/2017/A2the University of Macau MYRG2022-00023-FHSThe University of Macau 2020-00094-FHSThe University of Macau MYRG2019-00018-FHSThe University of Macau SRG2017-00097-FHS
6 · The paper itself

Abstract

Pathogenic variation in DNA mismatch repair (MMR) gene

Indexed as

Colorectal Neoplasms, Hereditary NonpolyposisDeep LearningMutL Protein Homolog 1Databases, FactualDNA Mismatch RepairHumansMolecular Dynamics SimulationMLH1 protein, humanMutL Protein Homolog 1autoencoderdeep learningMLH1molecular dynamics simulationneural networkRamachandran plotVUS

Identifiers

PMID38255924
PMCPMC10815254
OpenAlexW4390695410

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.