Evidence map›Paper›PMID 38255821›Full record

ArticleInternational journal of molecular sciences2024

Functional Roles of CD26/DPP4 in Bleomycin-Induced Pulmonary Hypertension Associated with Interstitial Lung Disease.

Tadasu Okaya, Takeshi Kawasaki, Shun Sato, Yu Koyanagi, Koichiro Tatsumi, Ryo Hatano, Kei Ohnuma, Chikao Morimoto, Yoshitoshi Kasuya, Yoshinori Hasegawa and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Review
  3. Special Issue "Molecular Advances and Perspectives of Lung Disease".International journal of molecular sciences · 2025
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Tadasu OkayaDepartment of Respirology, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.
Takeshi KawasakiDepartment of Respirology, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.ORCID 0000-0002-1468-172X
Shun SatoDepartment of Respirology, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.
Yu KoyanagiDepartment of Respirology, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.
Koichiro TatsumiDepartment of Respirology, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.
Ryo HatanoDepartment of Therapy Development and Innovation for Immune Disorders and Cancers, Graduate School of Medicine, Juntendo University, Tokyo 113-8421, Japan.ORCID 0000-0002-2727-7275
Kei OhnumaDepartment of Therapy Development and Innovation for Immune Disorders and Cancers, Graduate School of Medicine, Juntendo University, Tokyo 113-8421, Japan.
Chikao MorimotoDepartment of Therapy Development and Innovation for Immune Disorders and Cancers, Graduate School of Medicine, Juntendo University, Tokyo 113-8421, Japan.
Yoshitoshi KasuyaDepartment of Biomedical Science, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.ORCID 0000-0003-0614-5836
Yoshinori HasegawaDepartment of Applied Genomics, Kazusa DNA Research Institute, Chiba 292-0818, Japan.
Osamu OharaDepartment of Applied Genomics, Kazusa DNA Research Institute, Chiba 292-0818, Japan.ORCID 0000-0002-3328-9571
Takuji SuzukiDepartment of Respirology, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.
Chiba University · JPJuntendo University · JPKazusa DNA Research Institute · JP

Funding

AMED 223fa627003h0001AMED-CREST JP21gm1210003GSK Japan Research Grant 2019Intractable Respiratory Diseases and Pulmonary Hypertension Research Group, Ministry of Health, Labor and Welfare, Japan 20FC1027, 23FC1031JSPS KAKENHI 19K17663, 22K16163JSPS KAKENHI 22H03076Therapeutics Research Initiative Grant from Chiba University School of Medicine 2019-G6
6 · The paper itself

Abstract

Pulmonary hypertension (PH) with interstitial lung diseases (ILDs) often causes intractable conditions. CD26/Dipeptidyl peptidase-4 (DPP4) is expressed in lung constituent cells and may be related to the pathogenesis of various respiratory diseases. We aimed to clarify the functional roles of CD26/DPP4 in PH-ILD, paying particular attention to vascular smooth muscle cells (SMCs).

Indexed as

Hypertension, PulmonaryLung Diseases, InterstitialOsteochondrodysplasiasAnimalsBleomycinDipeptidyl Peptidase 4HumansMiceMice, KnockoutPhosphatidylinositol 3-KinasesTransforming Growth Factor betaBleomycinDipeptidyl Peptidase 4Phosphatidylinositol 3-KinasesTransforming Growth Factor betaCD26dipeptidyl peptidase-4interstitial lung diseasepulmonary hypertension

Identifiers

PMID38255821
PMCPMC10815066
OpenAlexW4390672428

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.