ReviewChildren (Basel, Switzerland)2024
Wilson's Disease with Acute Hepatic Onset: How to Diagnose and Treat It.
Review in Children (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- False positive autoimmune markers and elevated immunoglobulin G in genetically confirmed Wilson disease.Journal of pediatric gastroenterology and nutrition · 2026Article
- Exploring the pathogenesis of a compound heterozygous variant in ATP7B associated with Wilson disease in an Iranian family.Molecular biology reports · 2026Article
- Efficacy of zinc monotherapy in a Wilson's disease adolescent with unusual renal onset: a case report and review of literature.BMC nephrology · 2026Review
- Diagnostic challenges and mimicking disorders of Wilson's Disease: A comprehensive review.Caspian journal of internal medicine · 2026Review
- Evaluation of the Relationship Between Neurologic Manifestations and Genetic Mutations in Wilson's Disease with Next-Generation Sequencing.Diagnostics (Basel, Switzerland) · 2025Article
- Alleviation of Copper-Induced Hepatotoxicity by Bergenin: Diminution of Oxidative Stress, Inflammation, and Apoptosis via Targeting SIRT1/FOXO3a/NF-κB Axes and p38 MAPK Signaling.Biological trace element research · 2025Article
- Article
- Unmasking the Duo: Wilson's Disease in the Context of Lupus and Existing Hepatitis E Coinfection.Clinical case reports · 2025Article
- Successful treatment of acute liver failure due to Wilson's disease: Serendipity or fortuity?World journal of hepatology · 2024Article
- Efficacy and safety of D-penicillamine, trientine, and zinc in pediatric Wilson disease patients.Orphanet journal of rare diseases · 2024Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Wilson's disease (WD) with acute onset poses a diagnostic challenge because it is clinically indistinguishable from other acute liver diseases. In addition, serum ceruloplasmin and urinary copper excretion, the first-line diagnostic tools for WD, can show false positive results in the case of acute liver failure, and the diagnostic role of genetic analysis is limited by the time required to perform it. In the case of fulminant onset, there is a clear indication of liver transplantation. "New Wilson Index" is frequently used to discriminate between patients who need liver transplantation versus those who can be successfully managed by medical treatment, but its reliability remains controversial. Timely referral of patients with acute liver failure due to WD may be a key factor in improving patient survival. Although liver transplant very often represents the only chance for such patients, maximum effort should be made to promote survival with a native liver. The management of these aspects of WD is still a matter of debate and will be the subject of this review.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.