ReviewChildren (Basel, Switzerland)2023
Update on Fever of Unknown Origin in Children: Focus on Etiologies and Clinical Approach.
Review in Children (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07074912 (Prescription Antipyretics to Decrease Unscheduled Return Visits In A Pediatric Emergency Department), which is not on this map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Prescription Antipyretics to Decrease Unscheduled Return Visits In A Pediatric Emergency Department
Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.
- Prolonged Fever in Children: An Inpatient Diagnostic Framework for Infections in Australia.Journal of paediatrics and child health · 2025Guideline
- Diagnostic value of basic and extended procedures in pediatric fever of unknown origin - results of a nation-wide surveillance study.Molecular and cellular pediatrics · 2026Article
- Possible Gastroenterological Causes of FUO (Fever of Unknown Origin).Journal of clinical medicine · 2026Review
- Persistent Fever as the Solitary Manifestation of Familial Mediterranean Fever: A Case Report.Cureus · 2026Article
- Clinical application value of metagenomic next-generation sequencing in children with fever of unknown origin.Frontiers in pediatrics · 2026Article
- Diagnostic Challenges in Pediatric Fever of Unknown Origin: Combined Role of Ferritin and Fever Duration.Children (Basel, Switzerland) · 2025Article
- Pediatric fever of unknown origin: Diagnostic spectrum revealed by a multidisciplinary retrospective study.European journal of pediatrics · 2025Article
- Prediction model for etiology of fever of unknown origin in children.European journal of pediatrics · 2025Article
- Reactivation of Latent Tuberculosis Following COVID-19 and Epstein-Barr Virus Coinfection: A Case Report.Pathogens (Basel, Switzerland) · 2025Article
- Castleman Disease-Still More Questions than Answers: A Case Report and Review of the Literature.Journal of clinical medicine · 2025Review
- Knowledge mapping of paediatric fever-a visual analysis based on CiteSpace.Frontiers in pediatrics · 2024Article
- Fever management in children and insights into fever of unknown origin: a survey among Italian pediatricians.Frontiers in pediatrics · 2024Article
- Fever of Unknown Origin in Children: A 14-Year, Single Institution Retrospective Review.Sage open pediatricsArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fever of unknown origin (FUO) can be caused by four etiological categories of diseases. The most common cause of FUO in children is represented by infections, followed by inflammatory conditions and neoplastic causes; a decreasing quote remains still without diagnosis. Despite the fact that several diagnostic and therapeutic approaches have been proposed since the first definition of FUO, none of them has been fully validated in pediatric populations. A focused review of the patient's history and a thorough physical examination may offer helpful hints in suggesting a likely diagnosis. The diagnostic algorithm should proceed sequentially, and invasive testing should be performed only in select cases, possibly targeted by a diagnostic suspect. Pioneering serum biomarkers have been developed and validated; however, they are still far from becoming part of routine clinical practice. Novel noninvasive imaging techniques have shown promising diagnostic accuracy; however, their positioning in the diagnostic algorithm of pediatric FUO is still not clear. This narrative review aims to provide a synopsis of the existent literature on FUO in children, with its major causes and possible diagnostic workup, to help the clinician tackle the complex spectrum of pediatric FUO in everyday clinical practice.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.