Evidence map›Paper›PMID 38255287›Full record

ArticleBiomedicines2024

The Relationship between Time, Race, and Estrogen Receptor Alpha in Estradiol-Induced Dermal Fibrosis.

DeAnna Baker Frost, Alisa Savchenko, Carol Feghali-Bostwick, Bethany Wolf

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedicines, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Observational
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

DeAnna Baker FrostDepartment of Medicine, Division of Rheumatology and Immunology, Medical University of South Carolina, 96 Jonathan Lucas Street, Charleston, SC 29425, USA.ORCID 0000-0002-9224-1391
Alisa SavchenkoChobanian & Avedisian School of Medicine, Boston University, 72 E. Concord Street, Boston, MA 02118, USA.
Carol Feghali-BostwickDepartment of Medicine, Division of Rheumatology and Immunology, Medical University of South Carolina, 96 Jonathan Lucas Street, Charleston, SC 29425, USA.ORCID 0000-0002-6750-6407
Bethany WolfDepartment of Public Health Sciences, Medical University of South Carolina, 135 Cannon Street, Room 305F, Charleston, SC 29425, USA.ORCID 0000-0002-7124-5158
Medical University of South Carolina · USBoston University · US

Funding

Scleroderma Twin Study and analysis of Estrogen in patients with dcSScK24AR060297 · NIAMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FEGHALI-BOSTWICK, CAROL A. · 2013 to 2025
$1.4M
The Role of Hormonal Dysregulation in Systemic SclerosisK08AR078372 · NIAMS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI DeAnna Baker Frost · 2022 to 2026
$935k
NIAMS NIH HHS K08 AR078372NIAMS NIH HHS K24 AR060297NIH HHS K08AR078372NIH HHS K24AR060297
6 · The paper itself

Abstract

In the skin, estradiol (E2) promotes profibrotic and proinflammatory cytokines, contributing to extracellular matrix (ECM) deposition. However, the magnitude of the response differs. Using the human skin organ culture model, we evaluated donor characteristics and correlations that contribute to E2-induced

Indexed as

estradiolestrogen receptor alphafibrosisskin

Identifiers

PMID38255287
PMCPMC10813671
OpenAlexW4390880445

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.