Evidence map›Paper›PMID 38255267›Full record

ArticleBiomedicines2024

Carriers of Heterozygous Loss-of-Function ACE Mutations Are at Risk for Alzheimer's Disease.

Sergei M Danilov, Ivan A Adzhubei, Alexander J Kozuch, Pavel A Petukhov, Isolda A Popova, Ananyo Choudhury, Dhriti Sengupta, Steven M Dudek

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedicines, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 12 citations in OpenAlex.

  1. Special Issue "Molecular Insight into Alzheimer's Disease".International journal of molecular sciences · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Sergei M DanilovDepartment of Medicine, Division of Pulmonary, Critical Care, Sleep and Allergy, University of Illinois Chicago, Chicago, IL 60612, USA.ORCID 0000-0002-6901-4545
Ivan A AdzhubeiDepartment of Biomedical Informatics, Harvard Medical School, Boston, MA 02115, USA.
Alexander J KozuchDepartment of Medicine, Division of Pulmonary, Critical Care, Sleep and Allergy, University of Illinois Chicago, Chicago, IL 60612, USA.ORCID 0009-0008-6506-6306
Pavel A PetukhovDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Illinois Chicago, Chicago, IL 60612, USA.
Isolda A PopovaToxicology Research Laboratory, University of Illinois Chicago, IL 60612, USA.
Ananyo ChoudhurySydney Brenner Institute for Molecular Bioscience, University of the Witwatersrand, Johannesburg 2193, South Africa.
Dhriti SenguptaSydney Brenner Institute for Molecular Bioscience, University of the Witwatersrand, Johannesburg 2193, South Africa.
Steven M DudekDepartment of Medicine, Division of Pulmonary, Critical Care, Sleep and Allergy, University of Illinois Chicago, Chicago, IL 60612, USA.ORCID 0000-0001-5624-0714
University of Illinois Urbana-Champaign · USUniversity of Illinois Chicago · USUniversity of the Witwatersrand · ZAHarvard University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We hypothesized that subjects with heterozygous loss-of-function (LoF)

Indexed as

angiotensin I-converting enzymeconformational changesmutationsplasma ACEscreening

Identifiers

PMID38255267
PMCPMC10813023
OpenAlexW4390820227

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.