Evidence map›Paper›PMID 38255235›Full record

ArticleBiomedicines2024

Levodopa Rescues Retinal Function in the Transgenic A53T Alpha-Synuclein Model of Parkinson's Disease.

Katie K N Tran, Vickie H Y Wong, Kirstan A Vessey, David I Finkelstein, Bang V Bui, Christine T O Nguyen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedicines, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Katie K N TranDepartment of Optometry and Vision Sciences, The University of Melbourne, Parkville, VIC 3010, Australia.
Vickie H Y WongDepartment of Optometry and Vision Sciences, The University of Melbourne, Parkville, VIC 3010, Australia.
Kirstan A VesseyDepartment of Anatomy and Physiology, The University of Melbourne, Parkville, VIC 3010, Australia.
David I FinkelsteinThe Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC 3010, Australia.ORCID 0000-0002-8167-4917
Bang V BuiDepartment of Optometry and Vision Sciences, The University of Melbourne, Parkville, VIC 3010, Australia.
Christine T O NguyenDepartment of Optometry and Vision Sciences, The University of Melbourne, Parkville, VIC 3010, Australia.ORCID 0000-0002-3298-3086
The University of Melbourne · AU

Funding

Australian Research Council LP160100126John Landman PhD Scholarship N/AMelbourne Neuroscience Institute Fellowship N/AMelbourne Neuroscience Institute Interdisciplinary Seed Fund N/AMelbourne Research Fellowship N/AMelbourne School of Health Sciences Seed Funding N/A
6 · The paper itself

Abstract

backgroundLoss of substantia nigra dopaminergic cells and alpha-synuclein (α-syn)-rich intraneuronal deposits within the central nervous system are key hallmarks of Parkinson's disease (PD). Levodopa (L-DOPA) is the current gold-standard treatment for PD. This study aimed to evaluate

methodsAnaesthetised 6-month-old mice expressing human A53T alpha-synuclein (HOM) and wildtype (WT) control littermates were intraperitoneally given 20 mg/kg L-DOPA (50 mg levodopa, 2.5 mg benserazide) or vehicle saline (

resultsWe found that photoreceptor (a-wave) and bipolar cell (b-wave) ERG responses (

conclusionsThese findings deepen our understanding of dopamine and alpha-synuclein interactions in the retina and provide a high-throughput preclinical framework, primed for translation, through which novel therapeutic compounds can be objectively screened and assessed for fast-tracking PD drug discovery.

Indexed as

A53T miceamacrine cellselectroretinographyimmunohistochemistrylevodopaoptical coherence tomographyParkinson’s disease

Identifiers

PMID38255235
PMCPMC10813165
OpenAlexW4390769817

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.