Evidence map›Paper›PMID 38255212›Full record

ArticleBiomedicines2024

Silica Nanoparticles Shed Light on Intriguing Cellular Pathways in Human Tracheal Smooth Muscle Cells: Revealing COX-2/PGE

Wen-Bin Wu, I-Ta Lee, Yan-Jyun Lin, Ssu-Ying Wang, Li-Der Hsiao, Chuen-Mao Yang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedicines, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.8field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Wen-Bin WuSchool of Medicine, Fu Jen Catholic University, New Taipei City 242062, Taiwan.ORCID 0000-0001-9248-5030
I-Ta LeeSchool of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei 110301, Taiwan.ORCID 0000-0002-8451-0280
Yan-Jyun LinInstitute of Translational Medicine and New Drug Development, College of Medicine, China Medical University, Taichung 406040, Taiwan.ORCID 0009-0001-9117-9362
Ssu-Ying WangGraduate Institute of Biomedical and Pharmaceutical Science, Fu Jen Catholic University, New Taipei City 242062, Taiwan.
Li-Der HsiaoGraduate Institute of Biomedical and Pharmaceutical Science, Fu Jen Catholic University, New Taipei City 242062, Taiwan.
Chuen-Mao YangGraduate Institute of Biomedical and Pharmaceutical Science, Fu Jen Catholic University, New Taipei City 242062, Taiwan.ORCID 0000-0002-3208-5438
Fu Jen Catholic University · TWChina Medical University · TWTaipei Medical University · TW

Funding

Chang Gung Medical Research Foundation, Taiwan CMRPG5M0161China Medical University, Taiwan CMU111-MF-26National Science and Technology Council, Taiwan NSTC111-2320-B-030-013
6 · The paper itself

Abstract

The use of manufactured silica nanoparticles (SiNPs) has become widespread in everyday life, household products, and various industrial applications. While the harmful effects of crystalline silica on the lungs, known as silicosis or chronic pulmonary diseases, are well understood, the impact of SiNPs on the airway is not fully explored. This study aimed to investigate the potential effects of SiNPs on human tracheal smooth muscle cells (HTSMCs). Our findings revealed that SiNPs induced the expression of cyclooxygenase-2 (COX-2) mRNA/protein and the production of prostaglandin E

Indexed as

airwaycyclooxygenase-2nanoparticlesprostaglandinsilica oxide

Identifiers

PMID38255212
PMCPMC10813532
OpenAlexW4390589463

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.