ReviewBiomedicines2023
The Impact of Biomarkers on the Early Detection of Acute Mesenteric Ischemia.
Review in Biomedicines, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 14 citations in OpenAlex.
- Diffuse Correlation Spectroscopy for Noninvasive Monitoring of Peripheral Perfusion During Cardiogenic Shock and VA-ECMO Support: An Experimental Study.Shock (Augusta, Ga.) · 2026Article
- Diagnostic and Prognostic Factors in Acute Intestinal Ischemia: A Comparative, Retrospective, Single-Center Cohort Study.Journal of clinical medicine · 2026Article
- Current Evidence on the Use of Biomarkers for the Diagnosis of Acute Mesenteric Ischemia: A Narrative Review.Cureus · 2026Review
- Predictive and Prognostic Biomarkers in Pediatric Intussusception-A Systematic Review.Journal of clinical medicine · 2026Review
- Representation and Utilization of Laboratory Data in CT-Based Acute Abdominal Emergency Radiology: A Methodological Content Analysis.Tomography (Ann Arbor, Mich.) · 2026Review
- Predicting In-Hospital Mortality in Acute Mesenteric Ischemia: The RADIAL Score.Journal of clinical medicine · 2026Article
- Integrated Radiology-Biochemistry Diagnostic Flow Framework for Emergency Clinical Decision Support: A Simulation-Based Educational Model.Tomography (Ann Arbor, Mich.) · 2026Article
- Porto-spleno-mesenteric thrombosis secondary to medroxyprogesterone acetate as a treatment for abnormal uterine bleeding: a case report.Journal of surgical case reports · 2025Article
- Diagnostic utility of inflammatory ratios and nutritional scores in acute mesenteric ischemia: A retrospective single-center study.Turkish journal of surgery · 2025Article
- Longitudinal analysis of serum intestinal fatty acid-binding protein in a patient with non-occlusive mesenteric ischemia following brachial plexus block-induced hypotension: a case study.Clinical journal of gastroenterology · 2025Article
- Deep learning-assisted diagnosis of acute mesenteric ischemia based on CT angiography images.Frontiers in medicine · 2025Article
- Ischemic colitis presenting as a colonic mass: a case report and diagnostic challenges.Frontiers in medicine · 2024Article
- Peripheral Blood Levels of IL-27, IFABP, and DAO at Early Onset as Predictors of 28-Day Mortality in Enterogenic Sepsis Patients: A Single-Center, Prospective Pilot Study.Infection and drug resistance · 2024Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundacute mesenteric ischemia (AMI) is a life-threatening condition that is caused by inadequate blood flow through the mesenteric vessel and is related to high mortality rates due to systemic complications. This study aims to systematically review the available literature concerning the major findings of possible biomarkers for early detection of acute mesenteric ischemia in the human population.
methodsstudies that measured the performance of biomarkers during acute mesenteric ischemia were identified with the search of PubMed, Embase, Medline, and Cochrane library.
resultsfrom a total of 654 articles, 46 articles examining 14 different biomarkers were filtered, falling within our inclusion criteria. Intestinal fatty acid-binding protein (I-FABP) was the most commonly researched biomarker regarding AMI, with sensitivity ranging from 61.5% to 100% and specificity ranging from 40% to 100%. The second most commonly researched biomarker was D-dimer, with a sensitivity of 60-100% and a specificity of 18-85.71%. L-lactate had a sensitivity of 36.6-90.91% and a specificity of 64.29-96%. Several parameters within the blood count were examined as potential markers for AMI, including NLR, PLR, MPV, RDW, DNI, and IG. Citrulline, interleukin 6 (IL-6), and procalcitonin (PCT) were the least-researched biomarkers.
conclusiondifferent biomarkers showed different accuracies in detecting AMI. I-FABP and D-dimer have been the most researched and shown to be valuable in the diagnosis of AMI, whereas L-lactate could be used as an additional tool. Ischemia-modified albumin (IMA), alpha glutathione S-transferase (αGST), interleukin 6 (IL-6), and citrulline showed potential use in their respective studies. However, further research needs to be done on larger sample sizes and with controls to reduce bias. Several studies showed that neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), mean platelet volume (MPV), red-cell distribution width (RDW), delta neutrophil index (DNI), and immature granulocytes (IGs) might be useful, as well at the same time be widely distributed and affordable in combination with other markers presenting higher specificity and sensitivity.
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