Evidence map›Paper›PMID 38255181›Full record

ArticleBiomedicines2023

Hypoxia Dysregulates the Transcription of Myoendothelial Junction Proteins Involved with Nitric Oxide Production in Brain Endothelial Cells.

Gregory Thomas, Kaysie L Banton, Raymond Garrett, Carlos H Palacio, David Acuna, Robert Madayag, David Bar-Or

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedicines, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 70% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Gregory ThomasTrauma and Stroke Research Lab, 601 East Hampden Ave, Englewood, CO 80113, USA.
Kaysie L BantonTrauma and Surgery Services, Swedish Medical Center, 501 East Hampden Ave, Englewood, CO 80113, USA.
Raymond GarrettTrauma and Stroke Research Lab, 601 East Hampden Ave, Englewood, CO 80113, USA.
Carlos H PalacioTrauma and Surgery Services, South Texas Health System-McAllen, 301 West Expressway 83, McAllen, TX 78503, USA.
David AcunaTrauma and Surgery Services, Wesley Medical Center, 550 North Hillside St, Wichita, KS 67214, USA.
Robert MadayagTrauma and Surgery Services, Lutheran Medical Center, 8300 W. 38th Ave, Wheat Ridge, CO 80033, USA.
David Bar-OrTrauma and Stroke Research Lab, 601 East Hampden Ave, Englewood, CO 80113, USA.ORCID 0000-0002-3685-314X
Lutheran Medical Center · USRocky Vista University · USSwedish Medical Center · USWesley Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Myoendothelial junctions (MEJs) are structures that allow chemical signals to be transmitted between endothelial cells (ECs) and vascular smooth muscle cells, which control vascular tone. MEJs contain hemoglobin alpha (Hbα) and endothelial nitric oxide synthase (eNOS) complexes that appear to control the production and scavenging of nitric oxide (NO) along with the activity of cytochrome b5 reductase 3 (CYB5R3). The aim of this study was to examine how hypoxia affected the regulation of proteins involved in the production of NO in brain ECs. In brief, human brain microvascular endothelial cells (HBMEC) were exposed to cobalt chloride (CoCl

Indexed as

cytochrome b5 reductase 3 myoendothelial junctionendothelial nitric oxide synthasehemoglobin alphanitric oxide

Identifiers

PMID38255181
PMCPMC10813549
OpenAlexW4390338978

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.