Evidence map›Paper›PMID 38255002›Full record

ArticleGenes2024

Idiopathic Epilepsy Risk Allele Trends in Belgian Tervuren: A Longitudinal Genetic Analysis.

Nathan Kinsey, Janelle M Belanger, Paul J J Mandigers, Peter A Leegwater, Tiina Heinonen, Marjo K Hytönen, Hannes Lohi, Elaine A Ostrander, Anita M Oberbauer

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Nathan KinseyDepartment of Animal Science, University of California, Davis, CA 95616, USA.ORCID 0000-0003-2789-1299
Janelle M BelangerDepartment of Animal Science, University of California, Davis, CA 95616, USA.ORCID 0000-0002-3703-260X
Paul J J MandigersDepartment of Clinical Sciences, Utrecht University, Yalelaan 108, 3584 CM Utrecht, The Netherlands.ORCID 0000-0003-2547-6673
Peter A LeegwaterDepartment of Clinical Sciences, Utrecht University, Yalelaan 108, 3584 CM Utrecht, The Netherlands.
Tiina HeinonenDepartment of Medical and Clinical Genetics, University of Helsinki, 00014 Helsinki, Finland.
Marjo K HytönenDepartment of Medical and Clinical Genetics, University of Helsinki, 00014 Helsinki, Finland.ORCID 0000-0003-1976-5874
Hannes LohiDepartment of Medical and Clinical Genetics, University of Helsinki, 00014 Helsinki, Finland.ORCID 0000-0003-1087-5532
Elaine A OstranderNational Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0001-6075-9738
Anita M OberbauerDepartment of Animal Science, University of California, Davis, CA 95616, USA.
University of California, Davis · USUniversity of Helsinki · FIUtrecht University · NLNational Institutes of Health · US

Funding

Comparative Mammalian GenomicsZIAHG200377 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI OSTRANDER, ELAINE · 2012 to 2025
$24.8M
American Kennel Club Canine Health Foundation 02936
6 · The paper itself

Abstract

Idiopathic epilepsy (IE) has been known to be inherited in the Belgian Tervuren for many decades. Risk genotypes for IE in this breed have recently been identified on Canis familiaris chromosomes (CFA) 14 and 37. In the current study, the allele frequencies of these loci were analyzed to determine whether dog breeders had employed a purposeful selection against IE, leading to a reduction in risk-associated allele frequency within the breed over time. The allele frequencies of two generational groupings of Belgian Tervuren with and without IE were compared. Allele frequencies for risk-associated alleles on CFA14 were unchanged between 1985 and 2015, whereas those on CFA37 increased during that time in the control population (

Indexed as

EpilepsyAllelesAnimalsBelgiumDogsGene FrequencySeizuresBelgian Tervurendogidiopathic epilepsyneurological disorderseizureselective breeding

Identifiers

PMID38255002
PMCPMC10815166
OpenAlexW4390975162

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.