Evidence map›Paper›PMID 38254990›Full record

ArticleGenes2024

Differential Interferon Signaling Regulation and Oxidative Stress Responses in the Cerebral Cortex and Cerebellum Could Account for the Spatiotemporal Pattern of Neurodegeneration in Niemann-Pick Disease Type C.

Andrew J Tolan, Kayla L Sanchez, Samuel D Shin, Jacob B White, Antonio Currais, David Soriano-Castell, Christopher G Wilson, Pamela Maher, Salvador Soriano

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Andrew J TolanDepartment of Pathology and Human Anatomy, School of Medicine, Loma Linda University, Loma Linda, CA 92354, USA.ORCID 0000-0002-7886-1674
Kayla L SanchezDepartment of Pathology and Human Anatomy, School of Medicine, Loma Linda University, Loma Linda, CA 92354, USA.
Samuel D ShinDepartment of Pathology and Human Anatomy, School of Medicine, Loma Linda University, Loma Linda, CA 92354, USA.
Jacob B WhiteDepartment of Pathology and Human Anatomy, School of Medicine, Loma Linda University, Loma Linda, CA 92354, USA.
Antonio CurraisThe Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.
David Soriano-CastellThe Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.ORCID 0000-0002-1235-1671
Christopher G WilsonLawrence D. Longo Center for Perinatal Biology, School of Medicine, Loma Linda University, Loma Linda, CA 92354, USA.
Pamela MaherThe Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.ORCID 0000-0003-0694-0610
Salvador SorianoDepartment of Pathology and Human Anatomy, School of Medicine, Loma Linda University, Loma Linda, CA 92354, USA.ORCID 0000-0002-6369-4586
Loma Linda University · USSalk Institute for Biological Studies · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Niemann-Pick disease type C (NPC) is a fatal neurodegenerative condition caused by genetic mutations of the

Indexed as

Niemann-Pick Disease, Type CAnimalsCerebellumCerebral CortexInterferonsMiceOxidative StressInterferonsinterferon signalingneurodegenerationNiemann–Pick disease type C

Identifiers

PMID38254990
PMCPMC10815326
OpenAlexW4390880232

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.