Evidence map›Paper›PMID 38254961›Full record

ArticleGenes2024

Cerebrospinal Fluid C1-Esterase Inhibitor and Tie-1 Levels Affect Cognitive Performance: Evidence from Proteome-Wide Mendelian Randomization.

Loukas Zagkos, Marie-Joe Dib, Héléne T Cronjé, Paul Elliott, Abbas Dehghan, Ioanna Tzoulaki, Dipender Gill, Iyas Daghlas

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 4 countries.

Loukas ZagkosDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London SW7 2BX, UK.ORCID 0000-0002-7700-8102
Marie-Joe DibDivision of Cardiovascular Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA.
Héléne T CronjéDepartment of Public Health, Section of Epidemiology, University of Copenhagen, 1165 Copenhagen, Denmark.
Paul ElliottDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London SW7 2BX, UK.
Abbas DehghanDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London SW7 2BX, UK.
Ioanna TzoulakiDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London SW7 2BX, UK.ORCID 0000-0002-4275-9328
Dipender GillDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London SW7 2BX, UK.ORCID 0000-0001-7312-7078
Iyas DaghlasDepartment of Neurology, University of California, San Francisco, San Francisco, CA 94143, USA.
Hammersmith Hospital · GBImperial College London · GBHospital of the University of Pennsylvania · USUniversity of California, San Francisco · USUniversity of Copenhagen · DK

Funding

Medical Research Council MR/S019669/1Medical Research Council UKWellcome TrustWellcome Trust 206046/Z/17/Z
6 · The paper itself

Abstract

objectiveThe association of cerebrospinal fluid (CSF) protein levels with cognitive function in the general population remains largely unexplored. We performed Mendelian randomization (MR) analyses to query which CSF proteins may have potential causal effects on cognitive performance. METHODS AND ANALYSIS: Genetic associations with CSF proteins were obtained from a genome-wide association study conducted in up to 835 European-ancestry individuals and for cognitive performance from a meta-analysis of GWAS including 257,841 European-ancestry individuals. We performed Mendelian randomization (MR) analyses to test the effect of randomly allocated variation in 154 genetically predicted CSF protein levels on cognitive performance. Findings were validated by performing colocalization analyses and considering cognition-related phenotypes.

resultsGenetically predicted C1-esterase inhibitor levels in the CSF were associated with a better cognitive performance (SD units of cognitive performance per 1 log-relative fluorescence unit (RFU): 0.23, 95% confidence interval: 0.12 to 0.35,

conclusionsHuman genetics supports a role for the C1-esterase inhibitor and sTie-1 in cognitive performance.

Indexed as

Complement C1 Inhibitor ProteinProteomeCognitionEsterasesGenome-Wide Association StudyHumansMendelian Randomization AnalysisMeta-Analysis as TopicReceptor, TIE-1Complement C1 Inhibitor ProteinEsterasesProteomeReceptor, TIE-1SERPING1 protein, humanTIE1 protein, humancognitionCSFSERPING1TIE1tyrosine-protein kinase receptor

Identifiers

PMID38254961
PMCPMC10815381
OpenAlexW4390581616

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.