Evidence map›Paper›PMID 38254837›Full record

ArticleCancers2024

Mean Oral Cavity Organ-at-Risk Dose Predicts Opioid Use and Hospitalization during Radiotherapy for Patients with Head and Neck Tumors.

Robert L Foote, W Scott Harmsen, Adam C Amundson, Alan B Carr, Mauricio E Gamez, Yolanda I Garces, Scott C Lester, Daniel J Ma, Lisa A McGee, Eric J Moore and 8 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 2 institutions in 1 country.

Robert L FooteDepartment of Radiation Oncology, Mayo Clinic, 200 First St. SW, Rochester, MN 55905, USA.ORCID 0000-0003-3470-6872
W Scott HarmsenDepartment of Quantitative Health Sciences, Mayo Clinic, 200 First St. SW, Rochester, MN 55905, USA.
Adam C AmundsonDepartment of Radiation Oncology, Mayo Clinic, 200 First St. SW, Rochester, MN 55905, USA.
Alan B CarrDepartment of Dental Specialties, Division of Esthetic and Prosthetic Dentistry, Department of Advanced Prosthodontics, Mayo Clinic, 200 First St. SW, Rochester, MN 55905, USA.
Mauricio E GamezDepartment of Radiation Oncology, Mayo Clinic, 200 First St. SW, Rochester, MN 55905, USA.
Yolanda I GarcesDepartment of Radiation Oncology, Mayo Clinic, 200 First St. SW, Rochester, MN 55905, USA.
Scott C LesterDepartment of Radiation Oncology, Mayo Clinic, 200 First St. SW, Rochester, MN 55905, USA.ORCID 0000-0001-5264-9811
Daniel J MaDepartment of Radiation Oncology, Mayo Clinic, 200 First St. SW, Rochester, MN 55905, USA.
Lisa A McGeeDepartment of Radiation Oncology, Mayo Clinic Arizona, 5777 E. Mayo Blvd., Phoenix, AZ 85054, USA.
Eric J MooreDepartment of Otolaryngology-Head and Neck Surgery, Mayo Clinic, 200 First St. SW, Rochester, MN 55905, USA.
Michelle A Neben WittichDepartment of Radiation Oncology, Mayo Clinic, 200 First St. SW, Rochester, MN 55905, USA.
Samir H PatelDepartment of Radiation Oncology, Mayo Clinic Arizona, 5777 E. Mayo Blvd., Phoenix, AZ 85054, USA.
David M RoutmanDepartment of Radiation Oncology, Mayo Clinic, 200 First St. SW, Rochester, MN 55905, USA.
Jean-Claude M RwigemaDepartment of Radiation Oncology, Mayo Clinic Arizona, 5777 E. Mayo Blvd., Phoenix, AZ 85054, USA.
Kathryn M Van AbelDepartment of Otolaryngology-Head and Neck Surgery, Mayo Clinic, 200 First St. SW, Rochester, MN 55905, USA.
Linda X YinDepartment of Otolaryngology-Head and Neck Surgery, Mayo Clinic, 200 First St. SW, Rochester, MN 55905, USA.ORCID 0000-0001-8515-2051
Olivia M MullerDepartment of Dental Specialties, Division of Esthetic and Prosthetic Dentistry, Department of Advanced Prosthodontics, Mayo Clinic, 200 First St. SW, Rochester, MN 55905, USA.
Satomi ShiraishiDivision of Medical Physics, Mayo Clinic, 200 First St. SW, Rochester, MN 55905, USA.
Mayo Clinic · USWinnMed · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundApproximately 75% of all head and neck cancer patients are treated with radiotherapy (RT). RT to the oral cavity results in acute and late adverse events which can be severe and detrimental to a patient's quality of life and function. The purpose of this study was to explore associations between RT dose to a defined oral cavity organ-at-risk (OAR) avoidance structure, provider- and patient-reported outcomes (PROs), opioid use, and hospitalization.

methodsThis was a retrospective analysis of prospectively obtained outcomes using multivariable modeling. The study included 196 patients treated with RT involving the oral cavity for a head and neck tumor. A defined oral cavity OAR avoidance structure was used in all patients for RT treatment planning. Validated PROs were collected prospectively. Opioid use and hospitalization were abstracted electronically from medical records.

resultsMultivariable modeling revealed the mean dose to the oral cavity OAR was significantly associated with opioid use (

conclusionsThe findings of this study may be valuable in RT treatment planning for patients with tumors of the head and neck region to reduce the need for opioid use and hospitalization during treatment.

Indexed as

adverse eventshead and neck canceroral cavityorgan at riskradiotherapy

Identifiers

PMID38254837
PMCPMC10814074
OpenAlexW4390882020

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.