ReviewCancers2024
Integrated Diagnostics of Thyroid Nodules.
Review in Cancers, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 4 syntheses or guidelines pooled it, 24 citations in OpenAlex.
- Impact of Diffusion-Weighted Magnetic Resonance Imaging Parameters on Diagnostic Accuracy for Thyroid Nodules: A Systematic Review and Meta-Analysis.Journal of magnetic resonance imaging : JMRI · 2026Pooled it
- Sociodemographic and clinical predictors of malignancy in thyroid nodules: a systematic review and meta-analysis.Frontiers in endocrinology · 2026Pooled it
- Pooled it
- Mapping the giants: a bibliometric analysis of the top 100 most-cited thyroid nodules studies.Frontiers in medicine · 2025Pooled it
- Doppler-Scintigraphy Combination with Thyroxine Profiling Enhances Diagnostic Accuracy of Thyroid Lesions: A 144-Patient Cross-Sectional Study.Journal of clinical medicine · 2026Article
- Designing a SPIKES-based protocol for communicating uncertainty in indeterminate thyroid cytology: a mixed-method analysis within a pilot study.Updates in surgery · 2026Article
- Beyond Size: Integrating Ultrasonographic Features and FNAB Cytology to Predict Thyroid Malignancy-A Retrospective, Single-Center Study.Journal of clinical medicine · 2026Article
- Artificial intelligence in thyroid ultrasound: clinical applications and perspectives.Frontiers in endocrinology · 2026Review
- Article
- The management of cytologically indeterminate thyroid nodules in clinical practice: A contemporary perspective with focus on molecular imaging.Endocrine · 2025Review
- Sonographic manifestations of multiple medullary carcinoma coexisting with papillary carcinoma of the thyroid: A case report.Radiology case reports · 2025Article
- Review
- Simultaneous Identification of Tc-99m-Sestamibi-Positive Autonomous Thyroid Adenoma and Adjacent F-18-Ethylcholine-Positive Parathyroid Adenoma in Patient with Graves' Disease Using Real-Time Ultrasound Fusion Imaging.Diagnostics (Basel, Switzerland) · 2025Article
- Improving fine needle aspiration in value-based thyroid cancer care: an interrupted time series analysis.Thyroid research · 2025Article
- Surveying the Digital Cytology Workflow in Italy: An Initial Report on AI Integration Across Key Professional Roles.Healthcare (Basel, Switzerland) · 2025Article
- Effects of Trace Elements on Endocrine Function and Pathogenesis of Thyroid Diseases-A Literature Review.Nutrients · 2025Review
- Exploring the psychological landscape of thyroid nodules: resilience, anxiety, and ultrasound correlations.Frontiers in psychology · 2025Article
- Review
- AI in Cytopathology: A Narrative Umbrella Review on Innovations, Challenges, and Future Directions.Journal of clinical medicine · 2024Review
- Diagnostic value of an interpretable machine learning model based on clinical ultrasound features for follicular thyroid carcinoma.Quantitative imaging in medicine and surgery · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Thyroid nodules are common findings, particularly in iodine-deficient regions. Our paper aims to revise different diagnostic tools available in clinical thyroidology and propose their rational integration. We will elaborate on the pros and cons of thyroid ultrasound (US) and its scoring systems, thyroid scintigraphy, fine-needle aspiration cytology (FNAC), molecular imaging, and artificial intelligence (AI). Ultrasonographic scoring systems can help differentiate between benign and malignant nodules. Depending on the constellation or number of suspicious ultrasound features, a FNAC is recommended. However, hyperfunctioning thyroid nodules are presumed to exclude malignancy with a very high negative predictive value (NPV). Particularly in regions where iodine supply is low, most hyperfunctioning thyroid nodules are seen in patients with normal thyroid-stimulating hormone (TSH) levels. Thyroid scintigraphy is essential for the detection of these nodules. Among non-toxic thyroid nodules, a careful application of US risk stratification systems is pivotal to exclude inappropriate FNAC and guide the procedure on suspicious ones. However, almost one-third of cytology examinations are rendered as indeterminate, requiring "diagnostic surgery" to provide a definitive diagnosis.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.