Evidence map›Paper›PMID 38254738›Full record

ReviewCancers2024

Melanoma Antigen Family A (MAGE A) as Promising Biomarkers and Therapeutic Targets in Bladder Cancer.

Shiv Verma, Diya Swain, Prem Prakash Kushwaha, Smit Brahmbhatt, Karishma Gupta, Debasish Sundi, Sanjay Gupta

Open access · goldAbstract readReview
In one paragraph

Review in Cancers, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Bladder (San Francisco, Calif.) · 2025
    Article
  7. Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Shiv VermaDepartment of Urology, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.ORCID 0000-0002-8270-6087
Diya SwainCollege of Arts and Sciences, Case Western Reserve University, Cleveland, OH 44106, USA.
Prem Prakash KushwahaDepartment of Urology, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.
Smit BrahmbhattCollege of Arts and Sciences, Case Western Reserve University, Cleveland, OH 44106, USA.
Karishma GuptaDepartment of Urology, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.
Debasish SundiDepartment of Urology, Division of Urologic Oncology, The Ohio State University Comprehensive Cancer Center, James Cancer Hospital & Wexner Medical Center, Columbus, OH 43210, USA.
Sanjay GuptaDepartment of Urology, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.ORCID 0000-0002-9492-3249
University Hospitals of Cleveland · USCase Western Reserve University · USThe Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute · US

Funding

Department of Defense W81XWH-19-1-0720United States Department of Defense W81XWH-18-1-0618
6 · The paper itself

Abstract

The Melanoma Antigen Gene (MAGE) is a large family of highly conserved proteins that share a common MAGE homology domain. Interestingly, many MAGE family members exhibit restricted expression in reproductive tissues but are abnormally expressed in various human malignancies, including bladder cancer, which is a common urinary malignancy associated with high morbidity and mortality rates. The recent literature suggests a more prominent role for MAGEA family members in driving bladder tumorigenesis. This review highlights the role of MAGEA proteins, the potential for them to serve as diagnostic or prognostic biomarker(s), and as therapeutic targets for bladder cancer.

Indexed as

biomarkersbladder cancercancer testis antigengenomic alterationsMelanoma Antigen Geneprotein–protein interactionsignaling pathwaystherapeutic target

Identifiers

PMID38254738
PMCPMC10813664
OpenAlexW4390614255

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.