Evidence map›Paper›PMID 38254717›Full record

ArticleBiomolecules2024

The Identification and Heterologous Expression of the Biosynthetic Gene Cluster Encoding the Antibiotic and Anticancer Agent Marinomycin.

Emily Abraham, Hannah A Lawther, Yunpeng Wang, Joseph S Zarins-Tutt, Gerry Sann Rivera, Chengcang Wu, Jack A Connolly, Gordon Florence, Matthias Agbo, Hong Gao and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Synthetic and systems biotechnology · 2026
    Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Emily AbrahamDepartment of Chemistry & BSRC, University of St. Andrews, St. Andrews KY16 9ST, UK.ORCID 0000-0002-8343-2524
Hannah A LawtherDepartment of Chemistry & BSRC, University of St. Andrews, St. Andrews KY16 9ST, UK.
Yunpeng WangDepartment of Chemistry & BSRC, University of St. Andrews, St. Andrews KY16 9ST, UK.
Joseph S Zarins-TuttDepartment of Chemistry & BSRC, University of St. Andrews, St. Andrews KY16 9ST, UK.
Gerry Sann RiveraIntact Genomics, St. Louis, MO 63132, USA.
Chengcang WuIntact Genomics, St. Louis, MO 63132, USA.
Jack A ConnollyDepartment of Chemistry & BSRC, University of St. Andrews, St. Andrews KY16 9ST, UK.ORCID 0000-0003-3643-5578
Gordon FlorenceDepartment of Chemistry & BSRC, University of St. Andrews, St. Andrews KY16 9ST, UK.
Matthias AgboDepartment of Chemistry & BSRC, University of St. Andrews, St. Andrews KY16 9ST, UK.ORCID 0000-0001-8210-306X
Hong GaoDepartment of Chemistry & BSRC, University of St. Andrews, St. Andrews KY16 9ST, UK.
Rebecca J M GossDepartment of Chemistry & BSRC, University of St. Andrews, St. Andrews KY16 9ST, UK.
University of St Andrews · GBIntact Genomics (United States) · US

Funding

EastBio studentship A BBSRC DTP ACH7 - BDTP18
6 · The paper itself

Abstract

With the rise in antimicrobial resistance, there is an urgent need for new classes of antibiotic with which to treat infectious disease. Marinomycin, a polyene antibiotic from a marine microbe, has been shown capable of killing methicillin-resistant

Indexed as

Antineoplastic AgentsMelanomaMethicillin-Resistant Staphylococcus aureusAnti-Bacterial AgentsHumansMultigene FamilyAnti-Bacterial AgentsAntineoplastic Agentsactinomyceteantibioticbiosynthetic gene clusterheterologous expressionmarine natural productmelanomaMRSAsynthetic biologyVREF

Identifiers

PMID38254717
PMCPMC10813093
OpenAlexW4390918858

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.