Evidence map›Paper›PMID 38254695›Full record

ArticleBiomolecules2024

GelMA/PEDOT:PSS Composite Conductive Hydrogel-Based Generation and Protection of Cochlear Hair Cells through Multiple Signaling Pathways.

Fei Tan, Xuran Li, Xiao Li, Maoxiang Xu, Khawar Ali Shahzad, Lei Hou

Open access · goldAbstract read
In one paragraph

Article in Biomolecules, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
3.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Review
  6. Advances in Microfluidic Cochlea-On-A-Chip.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  7. Article
  8. Review
  9. Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 3 countries.

Fei TanDepartment of ORL-HNS, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai 200070, China.ORCID 0000-0003-1010-0163
Xuran LiDepartment of ORL-HNS, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai 200070, China.
Xiao LiState Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Chemistry, Chemical Engineering and Biotechnology & Center for Advanced Low-Dimension Materials, Donghua University, Shanghai 200051, China.
Maoxiang XuDepartment of ORL-HNS, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai 200070, China.
Khawar Ali ShahzadDepartment of ORL-HNS, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai 200070, China.ORCID 0000-0003-3798-5301
Lei HouState Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Chemistry, Chemical Engineering and Biotechnology & Center for Advanced Low-Dimension Materials, Donghua University, Shanghai 200051, China.
Tongji University · CNDonghua University · CN

Funding

National Natural Science Foundation of China 82271192
6 · The paper itself

Abstract

Recent advances in cochlear implantology are exemplified by novel functional strategies such as bimodal electroacoustic stimulation, in which the patient has intact low-frequency hearing and profound high-frequency hearing pre-operatively. Therefore, the synergistic restoration of dysfunctional cochlear hair cells and the protection of hair cells from ototoxic insults have become a persistent target pursued for this hybrid system. In this study, we developed a composite GelMA/PEDOT:PSS conductive hydrogel that is suitable as a coating for the cochlear implant electrode for the potential local delivery of otoregenerative and otoprotective drugs. Various material characterization methods (e.g.,

Indexed as

Hair Cells, AuditoryHydrogelsAnimalsCell CommunicationHumansMiceSignal TransductionSpectroscopy, Fourier Transform InfraredHydrogelsapoptosiscochlear implantconductive hydrogelelectroacoustic stimulationferroptosisGelMAhair cellhair cell regenerationPEDOT:PSS

Identifiers

PMID38254695
PMCPMC10812993
OpenAlexW4390776720

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.