Evidence map›Paper›PMID 38254685›Full record

ArticleBiomolecules2024

Neurofilament Light Protein Rod Domain Exhibits Structural Heterogeneity.

Victoria V Nefedova, Sergey Y Kleymenov, Irina V Safenkova, Dmitrii I Levitsky, Alexander M Matyushenko

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Victoria V NefedovaResearch Centre of Biotechnology, Russian Academy of Sciences, 119071 Moscow, Russia.
Sergey Y KleymenovResearch Centre of Biotechnology, Russian Academy of Sciences, 119071 Moscow, Russia.ORCID 0000-0001-5085-0327
Irina V SafenkovaResearch Centre of Biotechnology, Russian Academy of Sciences, 119071 Moscow, Russia.ORCID 0000-0002-3621-4321
Dmitrii I LevitskyResearch Centre of Biotechnology, Russian Academy of Sciences, 119071 Moscow, Russia.ORCID 0000-0002-7755-9895
Alexander M MatyushenkoResearch Centre of Biotechnology, Russian Academy of Sciences, 119071 Moscow, Russia.

Funding

Ministry of Science and Higher Education of the Russian Federation
6 · The paper itself

Abstract

Neurofilaments are neuron-specific proteins that belong to the intermediate filament (IFs) protein family, with the neurofilament light chain protein (NFL) being the most abundant. The IFs structure typically includes a central coiled-coil rod domain comprised of coils 1A, 1B, and 2, separated by linker regions. The thermal stability of the IF molecule plays a crucial role in its ability for self-association. In the current study, we investigated the thermal stability of NFL coiled-coil domains by analyzing a set of recombinant domains and their fusions (NFL

Indexed as

Intermediate FilamentsTumor Necrosis Factor Ligand Superfamily Member 14Calorimetry, Differential ScanningNeuronsProtein DomainsTumor Necrosis Factor Ligand Superfamily Member 14AF4 platformcircular dichroismcoiled-coil structuredifferential scanning calorimetryneurofilament light chainprotein stability

Identifiers

PMID38254685
PMCPMC10813002

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.