Evidence map›Paper›PMID 38254684›Full record

ArticleBiomolecules2024

Kupffer Cell Inactivation Alters Endothelial Cell Adhesion Molecules in Cecal Ligation and Puncture-Induced Sepsis.

Sumeet Manandhar, Ravinder Reddy Gaddam, Stephen Chambers, Madhav Bhatia

Open access · goldAbstract read
In one paragraph

Article in Biomolecules, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. The Dual Role of Natural Killer Cells in the Septic Liver.Journal of inflammation research · 2026
    Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Sumeet ManandharDepartment of Pathology and Biomedical Science, University of Otago, Christchurch 8140, New Zealand.ORCID 0000-0002-5593-7357
Ravinder Reddy GaddamDepartment of Pathology and Biomedical Science, University of Otago, Christchurch 8140, New Zealand.ORCID 0000-0003-1062-5082
Stephen ChambersDepartment of Pathology and Biomedical Science, University of Otago, Christchurch 8140, New Zealand.
Madhav BhatiaDepartment of Pathology and Biomedical Science, University of Otago, Christchurch 8140, New Zealand.
University of Otago · NZ

Funding

Maurice and Phyllis Paykel TrustUniversity of Otago Vice-Chancellor's Strategic Development Fund
6 · The paper itself

Abstract

The activation of Kupffer cells, resident macrophages in the liver, is closely associated with the inflammatory response during sepsis, which leads to multiple-organ failure. However, how Kupffer cell activation affects adhesion molecules (ICAM-1 and VCAM-1) in sepsis has not been determined. This study investigated Kupffer cell inactivation's (by gadolinium chloride; GdCl

Indexed as

Kupffer CellsSepsisAnimalsEndothelial CellsIntercellular Adhesion Molecule-1MicePuncturesVascular Cell Adhesion Molecule-1Intercellular Adhesion Molecule-1Vascular Cell Adhesion Molecule-1adhesion moleculesendothelial cellsgadolinium chloridesepsis

Identifiers

PMID38254684
PMCPMC10813064
OpenAlexW4390748883

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.