Evidence map›Paper›PMID 38254677›Full record

ArticleBiomolecules2024

Synthesis and Characterization of a Novel Concentration-Independent Fluorescent Chloride Indicator, ABP-Dextran, Optimized for Extracellular Chloride Measurement.

Kieran P Normoyle, Kyle P Lillis, Kevin J Staley

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Kieran P NormoyleMassachusetts General Hospital, Department of Neurology, 55 Fruit Street, Boston, MA 02114, USA.ORCID 0000-0003-1375-5958
Kyle P LillisMassachusetts General Hospital, Department of Neurology, 55 Fruit Street, Boston, MA 02114, USA.
Kevin J StaleyMassachusetts General Hospital, Department of Neurology, 55 Fruit Street, Boston, MA 02114, USA.
Harvard University · US

Funding

Neuronal Ion and Volume Shifts After Acute Brain InjuryR35NS116852 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI Kevin J. Staley · 2020 to 2026
$8.0M
Neuronal Chloride distribution by displacementR01NS040109 · NINDS · UNIVERSITY OF COLORADO DENVER · PI STALEY, KEVIN J. · 2000 to 2020
$7.2M
Mechanisms of Interictal Spike GenerationR01NS112538 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI LILLIS, KYLE PATRICK · 2020 to 2024
$1.9M
NINDS NIH HHS 5R35NS116852NINDS NIH HHS R01 NS040109NINDS NIH HHS R01 NS112538NINDS NIH HHS R35 NS116852
6 · The paper itself

Abstract

GABA, the primary inhibitory neurotransmitter, stimulates GABAA receptors (GABAARs) to increase the chloride conductance of the cytosolic membrane. The driving forces for membrane chloride currents are determined by the local differences between intracellular and extracellular chloride concentrations (Cli and Clo, respectively). While several strategies exist for the measurement of Cli, the field lacks tools for non-invasive measurement of Clo. We present the design and development of a

Indexed as

ChloridesDextransColoring AgentsCytosolHalogensChloridesColoring AgentsDextransHalogensextracellular chlorideextracellular matrixfluorescence lifetime imagingfluorescent chloride sensorfluorescent dextran

Identifiers

PMID38254677
PMCPMC10813347
OpenAlexW4390662335

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.