Evidence map›Paper›PMID 38254650›Full record

ReviewBiomolecules2023

Biomolecules of Muscle Fatigue in Metabolic Myopathies.

Erika Schirinzi, Giulia Ricci, Francesca Torri, Michelangelo Mancuso, Gabriele Siciliano

Open access · goldAbstract readReview
In one paragraph

Review in Biomolecules, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Erika SchirinziDepartment of Clinical and Experimental Medicine, Neurological Clinic, University of Pisa, 56126 Pisa, Italy.
Giulia RicciDepartment of Clinical and Experimental Medicine, Neurological Clinic, University of Pisa, 56126 Pisa, Italy.
Francesca TorriDepartment of Clinical and Experimental Medicine, Neurological Clinic, University of Pisa, 56126 Pisa, Italy.
Michelangelo MancusoDepartment of Clinical and Experimental Medicine, Neurological Clinic, University of Pisa, 56126 Pisa, Italy.ORCID 0000-0003-2738-8562
Gabriele SicilianoDepartment of Clinical and Experimental Medicine, Neurological Clinic, University of Pisa, 56126 Pisa, Italy.ORCID 0000-0002-6142-2384
University of Pisa · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Metabolic myopathies are a group of genetic disorders that affect the normal functioning of muscles due to abnormalities in metabolic pathways. These conditions result in impaired energy production and utilization within muscle cells, leading to limitations in muscle function with concomitant occurrence of related signs and symptoms, among which fatigue is one of the most frequently reported. Understanding the underlying molecular mechanisms of muscle fatigue in these conditions is challenging for the development of an effective diagnostic and prognostic approach to test targeted therapeutic interventions. This paper outlines the key biomolecules involved in muscle fatigue in metabolic myopathies, including energy substrates, enzymes, ion channels, and signaling molecules. Potential future research directions in this field are also discussed.

Indexed as

Metabolism, Inborn ErrorsMuscular DiseasesHumansMuscle CellsMuscle FatigueMusclesbiomoleculesmetabolic myopathiesmuscle fatigue

Identifiers

PMID38254650
PMCPMC10812926
OpenAlexW4390459752

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.