Evidence map›Paper›PMID 38254641›Full record

ArticleBiomolecules2023

Exosome-Related FTCD Facilitates M1 Macrophage Polarization and Impacts the Prognosis of Hepatocellular Carcinoma.

Youyi Liu, Yifei Tang, Hongliang Jiang, Xiading Zhang, Xingyi Chen, Jingrou Guo, Cheng Jin, Minchen Wu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 17 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Review
  13. Review
  14. Review
  15. Review
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Youyi LiuWuxi School of Medicine, Jiangnan University, Wuxi 214122, China.
Yifei TangWuxi School of Medicine, Jiangnan University, Wuxi 214122, China.
Hongliang JiangWuxi School of Medicine, Jiangnan University, Wuxi 214122, China.
Xiading ZhangWuxi Higher Health Vocational Technology School, Wuxi 214000, China.
Xingyi ChenWuxi School of Medicine, Jiangnan University, Wuxi 214122, China.
Jingrou GuoWuxi School of Medicine, Jiangnan University, Wuxi 214122, China.
Cheng JinDepartment of Hepatobiliary Surgery, Affiliated Hospital of Jiangnan University, Jiangnan University, Wuxi 214041, China.
Minchen WuWuxi School of Medicine, Jiangnan University, Wuxi 214122, China.
Jiangnan University · CNWuxi Fourth People's Hospital · CNWuxi Vocational Institute of Commerce · CN

Funding

China Postdoctoral Science Foundation 2021M691278"Taihu lake" science and technology project of Wuxi K20221020
6 · The paper itself

Abstract

backgroundExosomes are essential for hepatocellular carcinoma (HCC) progression and have garnered significant interest as novel targets for diagnostic, prognostic, and therapeutic approaches. This study aims to identify potential exosome-related biomarkers for the development of useful strategies for HCC diagnosis and therapy.

methodsThree datasets obtained from the Gene Expression Omnibus (GEO) were utilized to identify differentially expressed genes (DEGs) in HCC. Through Gene Ontology (GO) analysis and protein-protein interaction (PPI) network, overall survival (OS) analysis, Cox analyses, and diethylnitrosamine (DEN)-induced HCC mouse model detection, exosome-related hub gene was screened out, followed by a prognostic value assessment and immune-correlates analysis based on the Cancer Genome Atlas (TCGA) dataset. The hub gene-containing exosomes derived from Hepa1-6 cells were isolated and characterized using differential ultracentrifugation, transmission electron microscopy scanning, and Western blot. Ultrasound-guided intrahepatic injection, cell co-culture, CCK-8, and flow cytometry were performed to investigate the effects of the hub gene on macrophage infiltration and polarization in HCC.

resultsA total of 83 DEGs enriched in the extracellular exosome term, among which, FTCD, HRA, and C8B showed the strongest association with the progression of HCC. FTCD was independently associated with a protective effect in HCC and selected as the hub gene. The presence of FTCD in exosomes was confirmed. FTCD-stimulated macrophages were polarized towards the M1 type and suppressed HCC cells proliferation.

conclusionsFTCD is a potential exosome-related biomarker for HCC diagnosis, prognosis, and treatment. The crosstalk between FTCD-containing exosomes and macrophages in HCC progression deserves further investigation.

Indexed as

Carcinoma, HepatocellularExosomesGlutamate FormimidoyltransferaseLiver NeoplasmsAmmonia-LyasesAnimalsBlotting, WesternMiceMice, Inbred StrainsMultifunctional EnzymesAmmonia-LyasesFtcd protein, mouseGlutamate FormimidoyltransferaseMultifunctional Enzymesbioinformatic analysisexosomeFTCDhepatocellular carcinomamacrophage infiltration

Identifiers

PMID38254641
PMCPMC10813691
OpenAlexW4390340832

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.