Evidence map›Paper›PMID 38254631›Full record

ArticleBiomolecules2023

Loss of the DYRK1A Protein Kinase Results in the Reduction in Ribosomal Protein Gene Expression, Ribosome Mass and Reduced Translation.

Chiara Di Vona, Laura Barba, Roberto Ferrari, Susana de la Luna

Open access · goldAbstract read
In one paragraph

Article in Biomolecules, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Up-regulation of Minibrain/DYRK1A contributes to macrocephaly and brain overgrowth in aProceedings of the National Academy of Sciences of the United States of America · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Chiara Di VonaCentre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology (BIST), Dr Aiguader 88, 08003 Barcelona, Spain.
Laura BarbaCentre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology (BIST), Dr Aiguader 88, 08003 Barcelona, Spain.
Roberto FerrariDepartment of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, Viale delle Scienze 23/A, 43124 Parma, Italy.ORCID 0000-0002-0453-0899
Susana de la LunaCentre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology (BIST), Dr Aiguader 88, 08003 Barcelona, Spain.ORCID 0000-0001-7765-916X
Centre for Biomedical Network Research on Rare Diseases · ESInstitució Catalana de Recerca i Estudis Avançats · ESUniversity of Parma · IT

Funding

Agency for Administration of University and Research 2021SGR01229Ministerio de Ciencia e Innovación BFU2016-76141-PMinisterio de Ciencia e Innovación PID2019-107185GB-I00Ministerio de Educación y Formación Profesional FPU13/02400
6 · The paper itself

Abstract

Ribosomal proteins (RPs) are evolutionary conserved proteins that are essential for protein translation. RP expression must be tightly regulated to ensure the appropriate assembly of ribosomes and to respond to the growth demands of cells. The elements regulating the transcription of RP genes (RPGs) have been characterized in yeast and

Indexed as

Dyrk KinasesRibosomal ProteinsAnimalsDrosophilaDrosophila ProteinsGene ExpressionHumansMammalsProtein KinasesRibosomesDrosophila ProteinsDYRK1A protein, humanDyrk Kinasesmnb protein, DrosophilaProtein KinasesRibosomal ProteinsDYRK1Aribosomal proteinsTCTCGCGAGAtranscriptiontranslation

Identifiers

PMID38254631
PMCPMC10813206
OpenAlexW4390197324

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.