Evidence map›Paper›PMID 38254422›Full record

ArticleAnimals : an open access journal from MDPI2024

Risk of Sperm Disorders and Impaired Fertility in Frozen-Thawed Bull Semen: A Genome-Wide Association Study.

Natalia V Dementieva, Artem P Dysin, Yuri S Shcherbakov, Elena V Nikitkina, Artem A Musidray, Anna V Petrova, Olga V Mitrofanova, Kirill V Plemyashov, Anastasiia I Azovtseva, Darren K Griffin and 1 more

Open access · goldAbstract read
In one paragraph

Article in Animals : an open access journal from MDPI, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
8.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Search for Ancient Selection Traces in Faverolle Chicken Breed (Animals : an open access journal from MDPI · 2025
    Article
  8. Review
  9. Article
  10. Genome-Wide Association Study of Reproductive Traits in Large White Pigs.Animals : an open access journal from MDPI · 2024
    Article
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Natalia V DementievaRussian Research Institute of Farm Animal Genetics and Breeding-Branch of the L. K. Ernst Federal Research Centre for Animal Husbandry, Pushkin, 196601 St. Petersburg, Russia.
Artem P DysinRussian Research Institute of Farm Animal Genetics and Breeding-Branch of the L. K. Ernst Federal Research Centre for Animal Husbandry, Pushkin, 196601 St. Petersburg, Russia.ORCID 0000-0002-4468-0365
Yuri S ShcherbakovRussian Research Institute of Farm Animal Genetics and Breeding-Branch of the L. K. Ernst Federal Research Centre for Animal Husbandry, Pushkin, 196601 St. Petersburg, Russia.
Elena V NikitkinaRussian Research Institute of Farm Animal Genetics and Breeding-Branch of the L. K. Ernst Federal Research Centre for Animal Husbandry, Pushkin, 196601 St. Petersburg, Russia.
Artem A MusidrayRussian Research Institute of Farm Animal Genetics and Breeding-Branch of the L. K. Ernst Federal Research Centre for Animal Husbandry, Pushkin, 196601 St. Petersburg, Russia.
Anna V PetrovaRussian Research Institute of Farm Animal Genetics and Breeding-Branch of the L. K. Ernst Federal Research Centre for Animal Husbandry, Pushkin, 196601 St. Petersburg, Russia.ORCID 0000-0001-8965-2002
Olga V MitrofanovaRussian Research Institute of Farm Animal Genetics and Breeding-Branch of the L. K. Ernst Federal Research Centre for Animal Husbandry, Pushkin, 196601 St. Petersburg, Russia.
Kirill V PlemyashovFederal State Budgetary Educational Institution of Higher Education "St. Petersburg State University of Veterinary Medicine", 196084 St. Petersburg, Russia.
Anastasiia I AzovtsevaRussian Research Institute of Farm Animal Genetics and Breeding-Branch of the L. K. Ernst Federal Research Centre for Animal Husbandry, Pushkin, 196601 St. Petersburg, Russia.
Darren K GriffinSchool of Biosciences, University of Kent, Canterbury CT2 7NJ, UK.ORCID 0000-0001-7595-3226
Michael N RomanovSchool of Biosciences, University of Kent, Canterbury CT2 7NJ, UK.ORCID 0000-0003-3584-4644
All-Russian Research Institute of Genetics and Farm Animal Breeding · RUUniversity of Kent · GBSaint Petersburg State University of Veterinary Medicine · RU

Funding

Ministry of Science and Higher Education of the Russian Federation Project No. FGGN-2024-0015
6 · The paper itself

Abstract

Cryopreservation is a widely used method of semen conservation in animal breeding programs. This process, however, can have a detrimental effect on sperm quality, especially in terms of its morphology. The resultant sperm disorders raise the risk of reduced sperm fertilizing ability, which poses a serious threat to the long-term efficacy of livestock reproduction and breeding. Understanding the genetic factors underlying these effects is critical for maintaining sperm quality during cryopreservation, and for animal fertility in general. In this regard, we performed a genome-wide association study to identify genomic regions associated with various cryopreservation sperm abnormalities in Holstein cattle, using single nucleotide polymorphism (SNP) markers via a high-density genotyping assay. Our analysis revealed a significant association of specific SNPs and candidate genes with absence of acrosomes, damaged cell necks and tails, as well as wrinkled acrosomes and decreased motility of cryopreserved sperm. As a result, we identified candidate genes such as

Indexed as

frozen-thawed bull semengenome-wide association studyHolstein cattlesingle nucleotide polymorphismsperm abnormalities

Identifiers

PMID38254422
PMCPMC10812825
OpenAlexW4390880895

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.