Evidence map›Paper›PMID 38254244›Full record

ArticleActa neuropathologica communications2024

A rare non-gadolinium enhancing sarcoma brain metastasis with microenvironment dominated by tumor-associated macrophages.

David Rogawski, Joshua Wheeler, Esther Nie, William Zhu, Eleanor Villanueva, Gwen Coffey, Qian Ma, Kristen Ganjoo, Nancy Fischbein, Michael Iv and 2 more

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta neuropathologica communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

David RogawskiDivision of Neuro-Oncology, Stanford Medicine, Stanford, CA, 94305, USA. rogawski@stanford.edu.ORCID 0009-0003-5587-5832
Joshua WheelerDivision of Neuropathology, Department of Pathology, Stanford Medicine, Stanford, CA, 94305, USA.
Esther NieDivision of Neuroimmunology, Stanford Medicine, Stanford, CA, 94305, USA.
William ZhuDepartment of Neurology and Neurological Sciences, Stanford Medicine, Stanford, CA, 94305, USA.
Eleanor VillanuevaDivision of Neuro-Oncology, Stanford Medicine, Stanford, CA, 94305, USA.
Gwen CoffeyDivision of Neuro-Oncology, Stanford Medicine, Stanford, CA, 94305, USA.
Qian MaDepartment of Neurology and Neurological Sciences, Stanford Medicine, Stanford, CA, 94305, USA.
Kristen GanjooDivision of Oncology, Department of Medicine, Stanford Medicine, Stanford, CA, 94305, USA.
Nancy FischbeinDivision of Neuroradiology, Department of Radiology, Stanford Medicine, Stanford, CA, 94305, USA.
Michael IvDivision of Neuroradiology, Department of Radiology, Stanford Medicine, Stanford, CA, 94305, USA.
Hannes VogelDivision of Neuropathology, Department of Pathology, Stanford Medicine, Stanford, CA, 94305, USA.
Seema NagpalDivision of Neuro-Oncology, Stanford Medicine, Stanford, CA, 94305, USA.
Stanford Medicine · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Brain metastases occur in 1% of sarcoma cases and are associated with a median overall survival of 6 months. We report a rare case of a brain metastasis with unique radiologic and histopathologic features in a patient with low grade fibromyxoid sarcoma (LGFMS) previously treated with immune checkpoint inhibitor (ICI) therapy. The lone metastasis progressed in the midbrain tegmentum over 15 months as a non-enhancing, T2-hyperintense lesion with peripheral diffusion restriction, mimicking a demyelinating lesion. Histopathology of the lesion at autopsy revealed a rich infiltrate of tumor-associated macrophages (TAMs) with highest density at the leading edge of the metastasis, whereas there was a paucity of lymphocytes, suggestive of an immunologically cold environment. Given the important immunosuppressive and tumor-promoting functions of TAMs in gliomas and carcinoma/melanoma brain metastases, this unusual case provides an interesting example of a dense TAM infiltrate in a much rarer sarcoma brain metastasis.

Indexed as

Brain NeoplasmsGliomaSarcomaBrainHumansTumor-Associated MacrophagesTumor MicroenvironmentBrain metastasisBrain tumor microenvironmentSarcomaTumor-associated macrophages

Identifiers

PMID38254244
PMCPMC10804641
OpenAlexW4391100084

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.