Evidence map›Paper›PMID 38254230›Full record

ArticleInternational journal of retina and vitreous2024

Serous maculopathy with absence of retinal pigment epithelium (SMARPE) associated with large drusen.

Luiz H Lima, João Pedro Romero Braga, Gustavo B Melo, Wener P Cella, Adam S L Brandão, Rodrigo L Meirelles, Claudio Zett, Francyne V R Cyrino, Rodrigo Jorge

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of retina and vitreous, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 97% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Luiz H LimaDepartment of Ophthalmology, Federal University of São Paulo (UNIFESP), Rua Botucatu, 821, Vila Clementino, São Paulo, 04023-062, Brazil. luizlima9@gmail.com.ORCID http://orcid.org/0000-0001-7304-909X
João Pedro Romero BragaDivision of Ophthalmology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.
Gustavo B MeloDepartment of Ophthalmology, Federal University of São Paulo (UNIFESP), Rua Botucatu, 821, Vila Clementino, São Paulo, 04023-062, Brazil.
Wener P CellaHospital de Referência Oftalmológica, São Luís, Maranhão, Brazil.
Adam S L BrandãoHospital de Referência Oftalmológica, São Luís, Maranhão, Brazil.
Rodrigo L MeirellesDepartment of Ophthalmology, Federal University of São Paulo (UNIFESP), Rua Botucatu, 821, Vila Clementino, São Paulo, 04023-062, Brazil.
Claudio ZettPontificia Universidad Católica de Valparaíso, Valparaíso, Chile.
Francyne V R CyrinoDivision of Ophthalmology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.
Rodrigo JorgeDivision of Ophthalmology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.
Universidade de São Paulo · BRUniversidade Federal de São Paulo · BRPontificia Universidad Católica de Valparaíso · CL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo describe the association of serous maculopathy with absence of retinal pigment epithelium (SMARPE) and large drusen in patients with non-neovascular age-related macular degeneration (AMD).

methodsA retrospective study of ophthalmic examination and multimodal imaging data of individuals with SMARPE and large drusen observed over a period of 12-month was accomplished. SMARPE was defined as subretinal accumulation of fluid within the macular area due to retinal pigment epithelium (RPE) aperture. Large drusen were identified by the presence of sub-RPE deposits using multimodal imaging analysis (color fundus photography, fundus autofluorescence, and spectral-domain optical coherence tomography).

resultsTwelve eyes of 7 white patients with a mean age of 77 years were observed to have SMARPE associated with large drusen. The median visual acuity was 20/100. Bilateral SMARPE lesions were observed in 71% of study patients. All SMARPE lesions were hypoautofluorescent, located in the subretinal space between the RPE and the ellipsoid zone, and presented as complete or incomplete RPE apertures associated with subretinal fluid. The SMARPE in this study had coincident multimodal imaging features as the SMARPE described in other reports in the literature.

conclusionsBilateral SMARPE can occur in association with typical AMD large drusen. Anomalisms resulting in drusen biogenesis or mechanisms that act alongside to these may be related to SMARPE development.

Indexed as

Age-related macular degenerationLarge drusenMultimodal imagingSerous maculopathy with absence of retinal pigment epithelium (SMARPE)

Identifiers

PMID38254230
PMCPMC10802009
OpenAlexW4391088843

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.