Evidence map›Paper›PMID 38254158›Full record

ArticleMolecular autism2024

Cortico-basal ganglia white matter microstructure is linked to restricted repetitive behavior in autism spectrum disorder.

Bradley J Wilkes, Derek B Archer, Anna L Farmer, Carly Bass, Hannah Korah, David E Vaillancourt, Mark H Lewis

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular autism, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
10.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Article
  3. Atypical Visually Guided Precision Grip Control in Middle-Aged and Older Autistic Adults.Autism research : official journal of the International Society for Autism Research · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Bradley J WilkesDepartment of Applied Physiology and Kinesiology, University of Florida, P.O. Box 118205, Gainesville, FL, 32611, USA. bwilkes@ufl.edu.
Derek B ArcherVanderbilt Memory and Alzheimer's Center, Department of Neurology, Vanderbilt School of Medicine, Nashville, TN, USA.
Anna L FarmerDepartment of Psychology, University of Florida, Gainesville, FL, USA.
Carly BassDepartment of Psychiatry, University of Florida, Gainesville, FL, USA.
Hannah KorahDepartment of Pharmacology, College of Medicine, University of Arizona, Tucson, AZ, USA.
David E VaillancourtDepartment of Applied Physiology and Kinesiology, University of Florida, P.O. Box 118205, Gainesville, FL, 32611, USA.
Mark H LewisDepartment of Psychology, University of Florida, Gainesville, FL, USA.
University of Florida · USUniversity of Arizona · USVanderbilt Health · US

Funding

Using social networks to map and evaluate team science across CTSA hubsUL1TR001427 · NCATS · UNIVERSITY OF FLORIDA · PI MITCHELL, DUANE A. · 2015 to 2024
$37.2M
NCATS NIH HHS UL1 TR001427NCATS NIH HHS UL1TR001427
6 · The paper itself

Abstract

backgroundRestricted repetitive behavior (RRB) is one of two behavioral domains required for the diagnosis of autism spectrum disorder (ASD). Neuroimaging is widely used to study brain alterations associated with ASD and the domain of social and communication deficits, but there has been less work regarding brain alterations linked to RRB.

methodsWe utilized neuroimaging data from the National Institute of Mental Health Data Archive to assess basal ganglia and cerebellum structure in a cohort of children and adolescents with ASD compared to typically developing (TD) controls. We evaluated regional gray matter volumes from T1-weighted anatomical scans and assessed diffusion-weighted scans to quantify white matter microstructure with free-water imaging. We also investigated the interaction of biological sex and ASD diagnosis on these measures, and their correlation with clinical scales of RRB.

resultsIndividuals with ASD had significantly lower free-water corrected fractional anisotropy (FA LIMITATIONS: The basal ganglia and cerebellar regions in this study were selected due to their hypothesized relevance to RRB. Differences between ASD and TD individuals that may occur outside the basal ganglia and cerebellum, and their potential relationship to RRB, were not evaluated.

conclusionsThese new findings demonstrate that cortico-basal ganglia white matter microstructure is altered in ASD and linked to RRB. FW in cortico-basal ganglia and intra-basal ganglia white matter was more sensitive to group differences in ASD, whereas cortico-basal ganglia FA

Indexed as

Autism Spectrum DisorderWhite MatterAdolescentBasal GangliaBrainChildHumansUnited StatesWaterWaterAutism spectrum disorderBasal gangliaCerebellumCortico-basal gangliaDiffusion tensor imagingFree-waterGray matterRestricted repetitive behaviorWhite matter

Identifiers

PMID38254158
PMCPMC10804694
OpenAlexW4391115350

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.