Evidence map›Paper›PMID 38254072›Full record

SynthesisBMC pulmonary medicine2024

Extracorporeal membrane oxygenation (ECMO) in patients with tuberculosis: systematic review and meta-analysis of 43 cases.

Raja Idris, Ann-Sophie Zielbauer, Julia Koepsell, Jan Kloka, Nils Wetzstein

Open access · goldAbstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in BMC pulmonary medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.5field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. ISCCM Position Statement on the Approach to and Management of Critically Ill Patients with Tuberculosis.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2024
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Raja Idris *Department of Internal Medicine, Infectious Diseases, Goethe University Frankfurt, University Hospital, Theodor-Stern-Kai 7, 60590, Frankfurt, Germany.ORCID http://orcid.org/0009-0004-1565-5859
Ann-Sophie Zielbauer *Department of Internal Medicine, Infectious Diseases, Goethe University Frankfurt, University Hospital, Theodor-Stern-Kai 7, 60590, Frankfurt, Germany. as.zielbauer@yahoo.de.ORCID http://orcid.org/0000-0003-3507-9217
Julia KoepsellDepartment of Internal Medicine, Infectious Diseases, Goethe University Frankfurt, University Hospital, Theodor-Stern-Kai 7, 60590, Frankfurt, Germany.ORCID http://orcid.org/0000-0003-1184-5327
Jan KlokaDepartment of Anaesthesiology, Intensive Care Medicine and Pain Therapy, Goethe University Frankfurt, University Hospital, Frankfurt, Germany.ORCID http://orcid.org/0000-0001-6890-3239
Nils WetzsteinDepartment of Internal Medicine, Infectious Diseases, Goethe University Frankfurt, University Hospital, Theodor-Stern-Kai 7, 60590, Frankfurt, Germany.ORCID http://orcid.org/0000-0002-5589-4668
Goethe University Frankfurt · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionTuberculosis (TB) is still a major contributor to the global health burden. Pulmonary TB can lead to life-threatening respiratory failure necessitating extracorporeal membrane oxygenation (ECMO) therapy. However, data on ECMO experience in the management of TB patients are scarce.

methodsWe conducted a systematic review of the literature using the search terms ECMO, extracorporeal membrane oxygenation, TB and tuberculosis in three databases (Medline, Web of Science and EMBASE). Clinical data were extracted by two independent investigators. Clinical parameters, such as mode of ECMO therapy, duration of treatment and clinical outcomes, were assessed.

resultsOverall, 43 patients from 15 countries were included in the analysis. The age ranged from 0 to 65 years, 39.5% were male, and 60.5% were female. The majority of patients suffered from ARDS (83.4%), with a mean Horovitz quotient of 68.1 (range 30.0-131.0). 83.7% received VV-ECMO, and 24.3% received VA-ECMO. Coinfections and complications were frequently observed (45.5% and 48.6% respectively). At the end of the respective observation period, the overall outcome was excellent, with 81.4% survival. DISCUSSION: ECMO therapy in TB patients appears to be a feasible therapeutic option, providing a bridge until antimycobacterial therapy takes effect. As the underlying cause is reversible, we advocate for the evaluation of ECMO usage in these patients with acute cardiac or respiratory failure.

Indexed as

CoinfectionExtracorporeal Membrane OxygenationRespiratory InsufficiencyTuberculosis, PulmonaryAdolescentAdultAgedChildChild, PreschoolFemaleHumansInfantInfant, NewbornMaleMiddle AgedYoung AdultECMOExtracorporeal membrane oxygenationTBTuberculosis

Identifiers

PMID38254072
PMCPMC10801979
OpenAlexW4391103961

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.